Product overview

Name Daminozide
Description Selective KDM2/7 histone demethylase inhibitor
Alternative names N-(dimethylamino)succinamic acid
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Biological Data

Biological description Selective KDM2/7 JmjC subfamily histone demethylase inhibitor (IC50 values are 0.55, 1.5 and 2.1 µM for PHF8, KDM2A and KDM7A respectively). Plant growth regulator.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in water (100mM) or DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Chemical name 1-(2,2-Dimethylhydrazide)butanedioi c acid
Molecular Weight 160.17
Chemical structure Daminozide  [1596-84-5] Chemical Structure
Molecular Formula C6H12N2O3
CAS Number 1596-84-5
PubChem identifier 15331
SMILES O=C(NN(C)C)CCC(O)=O
InChiKey NOQGZXFMHARMLW-UHFFFAOYSA-N

References for Daminozide

References are publications that support the biological activity of the product
  • Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases.

    Rose NR et al (2012) J Med Chem 55(14) : 6639-43.