Product overview

Name Cypermethrin
Purity >96%
Description Potent PP2B inhibitor
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Biological Data

Biological description Potent phosphatase 2B (PP2B) inhibitor (IC50 = 40 pM). Type II synthetic pyrethroid insecticide. Interacts with sodium channels producing neurotoxin effects. Also potent calcineurin inhibitor (IC50 = 100 nM). Blood brain barrier permeable.

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in ethanol (25mg/ml) or DMSO
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >96%
Molecular Weight 416.3
Chemical structure Cypermethrin  [52315-07-8] Chemical Structure
Molecular Formula C22H19Cl2NO3
CAS Number 52315-07-8
PubChem identifier 2912
SMILES CC1(C)C(\C=C(/Cl)Cl)C1C(=O)OC(C#N)C1=CC(OC2=CC=CC=C2)=CC=C1

References for Cypermethrin

References are publications that support the biological activity of the product
  • Effect of cypermethrin on memory, movement activity and coordination in mice after transient incomplete cerebral ischemia.

    Nieradko-Iwanicka B et al (2008) Pharmacol Rep 60(5) : 699-705.
  • Inhibition of phosphatase 2B prevents expression of hippocampal long-term potentiation.

    Wang JH et al (1994) Neuroreport 5(17) : 2377-80.
  • Specific inhibition of calcineurin by type II synthetic pyrethroid insecticides.

    Enan E et al (1992) Biochem Pharmacol 43(8) : 1777-84.
  • Specific inhibition of calcineurin by type II synthetic pyrethroid insecticides.

    Enan E et al (1992) Biochem Pharmacol 43(8) : 1777-84.

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