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Biological Data
| Biological description | Potent phosphatase 2B (PP2B) inhibitor (IC50 = 40 pM). Type II synthetic pyrethroid insecticide. Interacts with sodium channels producing neurotoxin effects. Also potent calcineurin inhibitor (IC50 = 100 nM). Blood brain barrier permeable. |
Solubility & Handling
| Storage instructions | +4°C |
| Solubility overview | Soluble in ethanol (25mg/ml) or DMSO |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical structure | ![Cypermethrin [52315-07-8] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "Cypermethrin [52315-07-8]") |
| Molecular Formula | C22H19Cl2NO3 |
| SMILES | CC1(C)C(\C=C(/Cl)Cl)C1C(=O)OC(C#N)C1=CC(OC2=CC=CC=C2)=CC=C1 |
References for Cypermethrin
References are publications that support the biological activity of the product
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Effect of cypermethrin on memory, movement activity and coordination in mice after transient incomplete cerebral ischemia.
Nieradko-Iwanicka B et al (2008) Pharmacol Rep 60(5) : 699-705. -
Inhibition of phosphatase 2B prevents expression of hippocampal long-term potentiation.
Wang JH et al (1994) Neuroreport 5(17) : 2377-80. -
Specific inhibition of calcineurin by type II synthetic pyrethroid insecticides.
Enan E et al (1992) Biochem Pharmacol 43(8) : 1777-84. -
Specific inhibition of calcineurin by type II synthetic pyrethroid insecticides.
Enan E et al (1992) Biochem Pharmacol 43(8) : 1777-84.
![Cypermethrin [52315-07-8] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb0222.png "Cypermethrin [52315-07-8]")
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