Product overview

Name Cyclosporin A
Alternative names Cyclosporine; Antibiotic S 7481F1; Ciclosporin A; CSA; cyclosporine A
Purity >99%
Description Potent calcineurin inhibitor. Inhibits MPTP opening.
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Biological Data

Biological description

Potent calcineurin inhibitor (IC50 = 5 nM) which inhibits mitochondrial permeability transition pore (MPTP) opening and also acts as a P-glycoprotein inhibitor.

Additionally, it increases AKT activation, displays immunosuppressive, tumor promoting and pro-angiogenic properties.

It also shows antiviral activity and inhibits the replication of diverse coronaviruses.

Solubility & Handling

Storage instructions -20°C (desiccate)
Solubility overview Soluble in DMSO (100mM) or ethanol (50mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Purity >99%
Molecular Weight 1202.63
Molecular Formula C62H111N11O12
CAS Number 59865-13-3
PubChem identifier 2909

References for Cyclosporin A

References are publications that support the biological activity of the product
  • The P-glycoprotein inhibitor cyclosporin A differentially influences behavioural and neurochemical responses to the antidepressant escitalopram.

    O'Brien FE et al (2014) Behav Brain Res 261 : 17-25.
  • Cyclosporin A Promotes Tumor Angiogenesis in a Calcineurin-Independent Manner by Increasing Mitochondrial Reactive Oxygen Species.

    Zhou AY et al (2014) Mol Cancer Res :
  • Cyclosporin A inhibits the replication of diverse coronaviruses

    Hemert et al (2011) J Gen Virol. (11) : 2542-2548
  • Immunosuppressive cyclosporin A activates AKT in keratinocytes through PTEN suppression: implications in skin carcinogenesis.

    Han W et al (2010) J Biol Chem 285(15) : 11369-77.
  • Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A.

    Fruman DA et al (1992) Proc Natl Acad Sci U S A 89(9) : 3686-90.

5 Item(s)