Product overview

Name Cystamine dihydrochloride
Description Transglutaminase inhibitor
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Biological Data

Biological description Transglutaminase inhibitor. Shows neuroprotective actions and acts as an antioxidant. Shows actions against Huntington's disease.

Solubility & Handling

Storage instructions room temperature (desiccate)
Solubility overview Soluble in water (100mM) or DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Chemical name 2,2'-Diaminodiethyl disulfide dihydrochloride
Molecular Weight 225.2
Chemical structure Cystamine dihydrochloride  [56-17-7] Chemical Structure
Molecular Formula C4H12N2S2.2HCl
CAS Number 56-17-7
PubChem identifier 5941
SMILES NCCSSCCN.Cl.Cl
InChiKey YUFRRMZSSPQMOS-UHFFFAOYSA-N

References for Cystamine dihydrochloride

References are publications that support the biological activity of the product
  • Oxidizing effects of exogenous stressors in Huntington's disease knock-in striatal cells--protective effect of cystamine and creatine.

    Ribeiro M et al (2013) Toxicol Sci 136(2) : 487-99.
  • Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase.

    Borrell-Pagès M et al (2006) J Clin Invest 116(5) : 1410-24.
  • Cystamine and cysteamine prevent 3-NP-induced mitochondrial depolarization of Huntington's disease knock-in striatal cells.

    Mao Z et al (2006) Eur J Neurosci 23(7) : 1701-10.
  • Therapeutic effects of cystamine in a murine model of Huntington's disease.

    Dedeoglu A et al (2002) J Neurosci 22(20) : 8942-50.