Microtubule

Cell permeable PKA activator

Potent, selective D₂-like receptor agonist

Classic 5-HT_1A partial agonist

Prototypic P2X₇ receptor agonist

Ceramide-activated protein phosphatase (CAPP) activator

TRPV1 channel agonist

K_2P2.1 (TREK-1) modulator. Used with ML336 as part of the CATKLAMP chemogenetic strategy. Selectively and irreversibly activates TREK-1^CG* but not wild-type K_2P2.1 (TREK-1)

Selective mGlu₅ positive allosteric modulator

Selective M₁ receptor agonist

Potent STING ligand