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BzATP triethylammonium salt

(HB1986)
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Product overview

Name BzATP triethylammonium salt
Purity >95%
Description Prototypic P2X7 receptor agonist
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (3) Frequently bought together
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Biological Data

Biological description

Prototypic P2X7 receptor agonist (EC50 = 3.6, 7 and 285 µM at rat, human and mouse receptors respectively). 5-10 times more potent than ATP at activating P2X7 receptors. Additionally shows activity at other P2 receptor (pEC50 values are 8.7, 7.1 and 6.1 at P2X1, P2X3, P2X2/3 respectively).

Also acts as an ATPase photoaffinity label. Evokes intracellular Yo-Pro-1 (Oxazole Yellow) accumulation.

Solubility & Handling

Solubility overview Soluble in water
Storage instructions -20°C
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >95%
Chemical name 2'(3')-O-(4-Benzoylbenzoyl)adenosine- 5'-triphosphate tri(triethylammonium) salt
Molecular Weight 1018.97
Chemical structure BzATP triethylammonium salt [112898-15-4] Chemical Structure
Molecular Formula C24H24N5O15P3.C18H45N3
CAS Number 112898-15-4
PubChem identifier 71308559
SMILES NC1=C2C(N([C@@H]3O[C@H](COP(OP(OP(O)([O-])=O)([O-])=O)([O-])=O)[C@@H](OC(C4=CC=C(C(C5=CC=CC=C5)=O)C=C4)=O)[C@H]3O)C=N2)=NC=N1.CC[NH+](CC)CC.CC[NH+](CC)CC.CC[NH+](CC)CC.NC6=C7C(N([C@@H]8O[C@H](COP(OP(OP(O)([O-])=O)([O-])=O)([O-])=O)[C@@H](O)[C@H]8OC(C9=CC=C(C(C%10=CC=CC=C%10)=O)C=C9)=O)C=N7)=NC=N6.CC[NH+](CC)CC.CC[NH+](CC)CC.CC[NH+](CC)CC
InChi InChI=1S/C24H24N5O15P3.C6H15N/c25-21-17-22(27-11-26-21)29(12-28-17)23-19(31)20(16(41-23)10-40-46(36,37)44-47(38,39)43-45(33,34)35)42-24(32)15-8-6-14(7-9-15)18(30)13-4-2-1-3-5-13;1-4-7(5-2)6-3/h1-9,11-12,16,19-20,23,31H,10H2,(H,36,37)(H,38,39)(H2,25,26,27)
InChiKey HVOVBTNCGADRTH-WBLDMZOZSA-N
MDL number MFCD00058547

References for BzATP triethylammonium salt

References are publications that support the biological activity of the product

  • Amino acid residues in the P2X7 receptor that mediate differential sensitivity to ATP and BzATP

    Young et al. (2007) Mol Pharmacol. 92-100 : 71(1)
    Read more (PubMedID: 17032903)

  • Pharmacological and molecular characterization of P2X receptors in rat pelvic ganglion neurons

    Zhong et al (1998) Br J Pharmacol. 771-81 : 125(4)
    Read more (PubMedID: 9831914)

  • The cytolytic P2Z receptor for extracellular ATP identified as a P2X receptor (P2X7)

    Surprenant et al (1996) Science. 5262 : 272
    Read more (PubMedID: 8614837)

3 Item(s)

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Order: HB1986
Pack PriceQty
1mg
$73
Prototypic P2X7 receptor agonist
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

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