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BzATP triethylammonium salt

(HB1986)
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Product overview

Name BzATP triethylammonium salt
Purity >95%
Description Prototypic P2X7 receptor agonist
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (3) Frequently bought together
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Biological Data

Biological description

Prototypic P2X7 receptor agonist (EC50 = 3.6, 7 and 285 µM at rat, human and mouse receptors respectively). 5-10 times more potent than ATP at activating P2X7 receptors. Additionally shows activity at other P2 receptor (pEC50 values are 8.7, 7.1 and 6.1 at P2X1, P2X3, P2X2/3 respectively).

Also acts as an ATPase photoaffinity label. Evokes intracellular Yo-Pro-1 (Oxazole Yellow) accumulation.

Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in water
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >95%
Chemical name 2'(3')-O-(4-Benzoylbenzoyl)adenosine- 5'-triphosphate tri(triethylammonium) salt
Molecular Weight 1018.97
Chemical structure BzATP triethylammonium salt [112898-15-4] Chemical Structure
Molecular Formula C24H24N5O15P3.C18H45N3
CAS Number 112898-15-4
PubChem identifier 71308559
SMILES NC1=C2C(N([C@@H]3O[C@H](COP(OP(OP(O)([O-])=O)([O-])=O)([O-])=O)[C@@H](OC(C4=CC=C(C(C5=CC=CC=C5)=O)C=C4)=O)[C@H]3O)C=N2)=NC=N1.CC[NH+](CC)CC.CC[NH+](CC)CC.CC[NH+](CC)CC.NC6=C7C(N([C@@H]8O[C@H](COP(OP(OP(O)([O-])=O)([O-])=O)([O-])=O)[C@@H](O)[C@H]8OC(C9=CC=C(C(C%10=CC=CC=C%10)=O)C=C9)=O)C=N7)=NC=N6.CC[NH+](CC)CC.CC[NH+](CC)CC.CC[NH+](CC)CC
InChi InChI=1S/C24H24N5O15P3.C6H15N/c25-21-17-22(27-11-26-21)29(12-28-17)23-19(31)20(16(41-23)10-40-46(36,37)44-47(38,39)43-45(33,34)35)42-24(32)15-8-6-14(7-9-15)18(30)13-4-2-1-3-5-13;1-4-7(5-2)6-3/h1-9,11-12,16,19-20,23,31H,10H2,(H,36,37)(H,38,39)(H2,25,26,27)
InChiKey HVOVBTNCGADRTH-WBLDMZOZSA-N
MDL number MFCD00058547

References for BzATP triethylammonium salt

References are publications that support the biological activity of the product

  • Amino acid residues in the P2X7 receptor that mediate differential sensitivity to ATP and BzATP

    Young et al. (2007) Mol Pharmacol. 92-100 : 71(1)
    Read more (PubMedID: 17032903)

  • Pharmacological and molecular characterization of P2X receptors in rat pelvic ganglion neurons

    Zhong et al (1998) Br J Pharmacol. 771-81 : 125(4)
    Read more (PubMedID: 9831914)

  • The cytolytic P2Z receptor for extracellular ATP identified as a P2X receptor (P2X7)

    Surprenant et al (1996) Science. 5262 : 272
    Read more (PubMedID: 8614837)

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Order: HB1986
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1mg
$69
Prototypic P2X7 receptor agonist
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