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8-Bromo-cAMP sodium salt (8-Br-cAMP)

(HB0090)
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Product overview

Name 8-Bromo-cAMP sodium salt (8-Br-cAMP)
Purity >99%
Description

Cell permeable PKA activator

Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (3) Frequently bought together
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8-Bromo-cAMP sodium salt (8-Br-cAMP) product vial image | Hello Bio
8-Bromo-cAMP sodium salt (8-Br-cAMP) product vial image | Hello Bio

8-Bromo-cAMP sodium salt (8-Br-cAMP) product vial image | Hello Bio

8-Bromo-cAMP sodium salt (8-Br-cAMP) product vial image | Hello Bio

Biological Data

Biological description

Cell-permeable protein kinase A (PKA) activator. cAMP analog which has increased metabolic stability and membrane permeability compared with cAMP. Activates cAMP-dependent protein kinase with long-acting effects due to its resistance to cAMP phosphodiesterase (PDE).

Enhances the induction of pluripotency in human fibroblast cells by improving the reprogramming efficiency of human neonatal foreskin fibroblast (HFF1) cells in combination with VPA (valproic acid).

In combination with IBMX, also promotes the differentiation of human iPS cell–derived intestinal epithelial cells

Solubility & Handling

Storage instructions -20°C (desiccate)
Solubility overview Soluble in water (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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More Info

Dilution

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More Info

Chemical Data

Purity >99%
Chemical name 8-Bromoadenosine-3',5'-cyclic monophosphate sodium salt
Molecular Weight 430.09
Molecular Formula C10H10BrN5NaO6P
CAS Number 76939-46-3
PubChem identifier 23702958
SMILES [Na+].[H][C@@]12COP([O-])(=O)O[C@@]1([H])[C@@H](O)[C@@H](O2)N1C(Br)=NC2=C1N=CN=C2N
InChiKey DMRMZQATXPQOTP-GWTDSMLYSA-M
MDL number MFCD00005844

References for 8-Bromo-cAMP sodium salt (8-Br-cAMP)

References are publications that support the biological activity of the product

  • A cyclic AMP analog, 8-Br-cAMP, enhances the induction of pluripotency in human fibroblast cells.

    Wang Y et al (2011) Stem Cell Rev 7(2) : 331-41.
    Read more (PubMedID: 21120637)

  • Antidepressant-like activity of 8-Br-cAMP, a PKA activator, in the forced swim test.

    Brański P et al (2008) J Neural Transm 115(6) : 829-30.
    Read more (PubMedID: 18239846)

  • Dual effects of 8-Br-cAMP on differentiation and apoptosis of human esophageal cancer cell line Eca-109.

    Wang HM et al (2005) World J Gastroenterol 11(41) : 6538-42.
    Read more (PubMedID: 16425431)

3 Item(s)

Related Products
Grouped product items
Order: HB0090
Pack PriceQty
5mg
$30
25mg
$98
100mg
$286

Cell permeable PKA activator

Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

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