PI3K/Akt/mTOR

Akt / PDPK1 inhibitor

Potent dual PI3-K/mTOR inhibitor

Selective PPARγ agonist. Enhances mESCs proliferation and survival.

Dual ERK1/RasGAP inhibitor. Maintains ESC self-renewal.

Endogenous prostanoid. Induces hematopoietic stem cell proliferation. 3D growth matrix component and used in production of liver and prostate organoids.

mTOR inhibitor and potent immunosuppressant. Also used in inducible gene editing methods (e.g. CRISPR/Cas9) and promotes hPSC differentiation.

pan Class I PI3K isoforms inhibitor

Potent ATP competitive p38 MAPK inhibitor. 3D growth matrix component, promotes long-term organoid growth and can be used in production of gastric organoids. Promotes stability of human pluripotent stem cells.

Potent, selective p38 MAPK inhibitor. Stimulates neural stem cell proliferation.

Potent, selective cell permeable GSK-3 inhibitor. Maintains mESCs and promotes retinal stem cells proliferation.