Akt (PKB) and phosphatidylinositol 3-kinase (PDPK1) inhibitor (Ki values are 2.7 and 5.2 µM respectively). Binds at the pleckstrin homology (PH) domain of AKT and PDPK1. Shows anti-tumor and apoptotic actions.
Solubility & Handling
Storage instructions
-20°C
Solubility overview
Soluble in DMSO (100mM)
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References are publications that support the biological activity of the product
Molecular pharmacology and antitumor activity of PHT-427, a novel Akt/phosphatidylinositide-dependent protein kinase 1 pleckstrin homology domain inhibitor.
Meuillet EJ et al (2010) Mol Cancer Ther 9(3) : 706-17.
![PHT 427 [1191951-57-1] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb1251.png "PHT 427 [1191951-57-1]")
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