Product overview
| Name | PHT 427 |
| Description | Akt / PDPK1 inhibitor |
| Purity | >98% |
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Biological Data
| Biological description | Akt (PKB) and phosphatidylinositol 3-kinase (PDPK1) inhibitor (Ki values are 2.7 and 5.2 µM respectively). Binds at the pleckstrin homology (PH) domain of AKT and PDPK1. Shows anti-tumor and apoptotic actions. |
Solubility & Handling
| Storage instructions | -20°C |
| Solubility overview | Soluble in DMSO (100mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | 4-Dodecyl-N-1,3,4-thiadiazol-2-yl-benzenesulfonamide |
| Molecular Weight | 409.61 |
| Chemical structure | ![PHT 427 [1191951-57-1] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb1251.png "PHT 427 [1191951-57-1]") |
| Molecular Formula | C20H31N3O2S2 |
| CAS Number | 1191951-57-1 |
| PubChem identifier | 44240850 |
| SMILES | O=S(C(C=C1)=CC=C1CCCCCCCCCCCC)(NC2=NN=CS2)=O |
| InChiKey | BYWWNRBKPCPJMG-UHFFFAOYSA-N |
References for PHT 427
References are publications that support the biological activity of the product
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Molecular pharmacology and antitumor activity of PHT-427, a novel Akt/phosphatidylinositide-dependent protein kinase 1 pleckstrin homology domain inhibitor.
Meuillet EJ et al (2010) Mol Cancer Ther 9(3) : 706-17. -
In vitro and in vivo activity of novel small-molecule inhibitors targeting the pleckstrin homology domain of protein kinase B/AKT.
Moses SA et al (2009) Cancer Res 69(12) : 5073-81.
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