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Biological Data

Biological description Akt (PKB) and phosphatidylinositol 3-kinase (PDPK1) inhibitor (Ki values are 2.7 and 5.2 µM respectively). Binds at the pleckstrin homology (PH) domain of AKT and PDPK1. Shows anti-tumor and apoptotic actions.

Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Chemical Data

Chemical name 4-Dodecyl-N-1,3,4-thiadiazol-2-yl-benzenesulfonamide
Molecular Weight 409.61
Chemical structure PHT 427  [1191951-57-1] Chemical Structure
Molecular Formula C20H31N3O2S2
CAS Number 1191951-57-1
PubChem identifier 44240850
SMILES O=S(C(C=C1)=CC=C1CCCCCCCCCCCC)(NC2=NN=CS2)=O
InChiKey BYWWNRBKPCPJMG-UHFFFAOYSA-N

References for PHT 427

References are publications that support the biological activity of the product
  • Molecular pharmacology and antitumor activity of PHT-427, a novel Akt/phosphatidylinositide-dependent protein kinase 1 pleckstrin homology domain inhibitor.

    Meuillet EJ et al (2010) Mol Cancer Ther 9(3) : 706-17.
  • In vitro and in vivo activity of novel small-molecule inhibitors targeting the pleckstrin homology domain of protein kinase B/AKT.

    Moses SA et al (2009) Cancer Res 69(12) : 5073-81.