Product overview
| Name | PI 103 hydrochloride |
| Description | Potent dual PI3-K/mTOR inhibitor |
| Purity | >98% |
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Biological Data
| Biological description | Potent dual PI3-K/mTOR inhibitor with selectivity for PI3K family (IC 50 values are 2, 3, 3 and 15 nM at p110α, p110β, p110δ and p110γ and 20 and 83 nM at mTORC1 and mTORC2 respectively). Also shows activity at DNA-PK (IC50 = 14 nM). Shows antitumor activity and inhibits tumor cell invasion. Active in vivo. |
Solubility & Handling
| Storage instructions | +4°C (desiccate) |
| Storage buffer | Soluble in DMSO (20mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | 3-[4-(4-Morpholinylpyrido[3',2':4,5]f uro[3,2-d]pyrimidin-2-yl]phenol hydrochloride |
| Molecular Weight | 384.82 |
| Molecular Formula | C19H16N4O3.HCl |
| CAS Number | 371935-79-4 |
| PubChem identifier | 16739368 |
| SMILES | OC1=CC(C(N=C4N5CCOCC5)=NC3=C4OC2=NC=CC=C23)=CC=C1.Cl |
| InChiKey | XSQMYBFFYPTMFE-UHFFFAOYSA-N |
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