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Designer receptors exclusively activated by designer drugs (DREADDs) are genetically engineered GPCRs that are activated by physiologically inert synthetic small molecules (designer drugs) but not their endogenous ligand. Read our DREADDs mini-review or for practical advice on using these ligands in the lab see Stability of Water-Soluble DREADD Ligands in Solution: A Technical Review and Clozapine N-Oxide (freebase) - a technical review on stability, solubility and use in the lab).
NSC697923 (HB4001)
Description:Selective Ub-conjugating enzyme (E2) complex Ubc13-Uev1A inhibitor
Purity:>98%
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±-Octopamine hydrochloride (HB2791)
Description:Invertebrate neurotransmitter. Chemogenetic DmOctβ1 receptor activator.
Purity:>99%
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Okadaic Acid (HB0468)
Description:Potent, non-competitive protein phosphatase inhibitor
Purity:>98%
