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Biological Data
| Biological description | Potent, selective guanylyl cyclase inhibitor (IC50 = ~20 nM). Shows anxiolytic and anti-tumour actions. Also shows potential memory disturbing effects. |
Solubility & Handling
| Storage instructions | +4°C |
| Solubility overview | Soluble in DMSO (100mM) and in ethanol (20 mM, gentle warming) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | 1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one |
| Chemical structure | ![ODQ [41443-28-1] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "ODQ [41443-28-1]") |
| Molecular Formula | C9H5N3O2 |
| SMILES | C1=CC=C2C(=C1)N=CC3=NOC(=O)N23 |
| InChi | InChI=1S/C9H5N3O2/c13-9-12-7-4-2-1-3-6(7)10-5-8(12)11-14-9/h1-5H |
| InChiKey | LZMHWZHOZLVYDL-UHFFFAOYSA-N |
References for ODQ
References are publications that support the biological activity of the product
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In vivo microdialysis study of a specific inhibitor of soluble guanylyl cyclase on the glutamate receptor/nitric oxide/cyclic GMP pathway.
Fedele et al (1996) Br J Pharmacol 119(3) : 590-4 -
Nitric oxide-dependent long-term potentiation is blocked by a specific inhibitor of soluble guanylyl cyclase.
Boulton et al (1995) Neuroscienec 69(3) : 699-703 -
Potent and selective inhibition of nitric oxide-sensitive guanylyl cyclase by 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one.
Garthwaite et al (1995) Moll Pharmacol 48(2) : 184-8
Potent, selective guanylyl cyclase inhibitor
![ODQ [41443-28-1] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb2900.png "ODQ [41443-28-1]")
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