Product overview

Name Okadaic Acid
Alternative names OA
Purity >98%
Description Potent, non-competitive protein phosphatase inhibitor
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Okadaic Acid product vial image | Hello Bio

Biological Data

Biological description Potent and non-competitive protein phosphatase inhibitor. Exhibits higher selectivity for PP2A and PP1 over PCM (purified polycation-modulated) phosphatase and PP2B (ID50 values are 1.2, 315, 205 and 4530 nM respectively) yet little or no activity at PP2C. Displays apoptosis inducing properties with neurotoxic and tumor promoting effects. A diarrheic shellfish poisoning (DSP) toxin.

Solubility & Handling

Storage instructions -20°C (desiccate)
Solubility overview Soluble in DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Purity >98%
Chemical name 9,10-Deepithio-9,10-didehydroacanthifolicin
Molecular Weight 805.01
Chemical structure Okadaic Acid  [78111-17-8] Chemical Structure
Molecular Formula C44H68O13
CAS Number 78111-17-8
PubChem identifier 446512
SMILES C[C@@H]1CC[C@]2(CCCCO2)O[C@@H]1[C@@H](C)C[C@@H]([C@@H]3C(=C)[C@H]([C@H]4[C@H](O3)CC[C@]5(O4)CC[C@@H](O5)/C=C/[C@@H](C)[C@@H]6CC(=C[C@@]7(O6)[C@@H](CC[C@H](O7)C[C@](C)(C(=O)O)O)O)C)O)O
InChi InChI=1S/C44H68O13/c1-25-21-34(55-44(23-25)35(46)12-11-31(54-44)24-41(6,50)40(48)49)26(2)9-10-30-14-18-43(53-30)19-15-33-39(57-43)36(47)29(5)38(52-33)32(45)22-28(4)37-27(3)13-17-42(56-37)16-7-8-20-51-42/h9-10,23,26-28,30-39,45-47,50H,5,7-8,11-22,24H2,1-4,
MDL number MFCD00083455

References for Okadaic Acid

References are publications that support the biological activity of the product
  • Okadaic acid: more than a diarrheic toxin.

    Valdiglesias V et al (2013) Mar Drugs 11(11) : 4328-49.
  • Okadaic acid activates the PKR pathway and induces apoptosis through PKR stimulation in MG63 osteoblast-like cells.

    Haneji T et al (2013) Int J Oncol 42(6) : 1904-10.
  • Okadaic acid activates atypical protein kinase C (zeta/lambda) in rat and 3T3/L1 adipocytes. An apparent requirement for activation of Glut4 translocation and glucose transport.

    Standaert ML et al (1999) J Biol Chem 274(20) : 14074-8.
  • Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases. Specificity and kinetics.

    Bialojan C et al (1988) Biochem J 256(1) : 283-90.

4 Item(s)

These publications cite the use of Okadaic Acid purchased from Hello Bio:
  • PP2A protects podocytes against Adriamycin-induced injury and epithelial-to-mesenchymal transition via suppressing JIP4/p38-MAPK pathway

    Lu Z et al (2021) Cytotechnology 73(5) : 697-713
    PubMedID: 34629746

1 Item