Product overview

Name Okadaic Acid
Description Potent, non-competitive protein phosphatase inhibitor
Alternative names OA
Purity >98%
Write Your Own Review
You're reviewing:Okadaic Acid
Rate this item:

Biological Data

Biological description Potent and non-competitive protein phosphatase inhibitor. Exhibits higher selectivity for PP2A and PP1 over PCM (purified polycation-modulated) phosphatase and PP2B (ID50 values are 1.2, 315, 205 and 4530 nM respectively) yet little or no activity at PP2C. Displays apoptosis inducing properties with neurotoxic and tumor promoting effects. A diarrheic shellfish poisoning (DSP) toxin.

Solubility & Handling

Storage instructions -20°C (desiccate)
Solubility overview Soluble in DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

=
x
x
More Info

Dilution

x
=
x
More Info

Chemical Data

Chemical name 9,10-Deepithio-9,10-didehydroacanthifolicin
Molecular Weight 805.01
Chemical structure Okadaic Acid  [78111-17-8] Chemical Structure
Molecular Formula C44H68O13
CAS Number 78111-17-8
PubChem identifier 446512
SMILES C[C@@H]1CC[C@]2(CCCCO2)O[C@@H]1[C@@H](C)C[C@@H]([C@@H]3C(=C)[C@H]([C@H]4[C@H](O3)CC[C@]5(O4)CC[C@@H](O5)/C=C/[C@@H](C)[C@@H]6CC(=C[C@@]7(O6)[C@@H](CC[C@H](O7)C[C@](C)(C(=O)O)O)O)C)O)O
InChi InChI=1S/C44H68O13/c1-25-21-34(55-44(23-25)35(46)12-11-31(54-44)24-41(6,50)40(48)49)26(2)9-10-30-14-18-43(53-30)19-15-33-39(57-43)36(47)29(5)38(52-33)32(45)22-28(4)37-27(3)13-17-42(56-37)16-7-8-20-51-42/h9-10,23,26-28,30-39,45-47,50H,5,7-8,11-22,24H2,1-4,
InChiKey QNDVLZJODHBUFM-WFXQOWMNSA-N
MDL number MFCD00083455

References for Okadaic Acid

References are publications that support the biological activity of the product
  • Okadaic acid: more than a diarrheic toxin.

    Valdiglesias V et al (2013) Mar Drugs 11(11) : 4328-49.
  • Okadaic acid activates the PKR pathway and induces apoptosis through PKR stimulation in MG63 osteoblast-like cells.

    Haneji T et al (2013) Int J Oncol 42(6) : 1904-10.
  • Okadaic acid activates atypical protein kinase C (zeta/lambda) in rat and 3T3/L1 adipocytes. An apparent requirement for activation of Glut4 translocation and glucose transport.

    Standaert ML et al (1999) J Biol Chem 274(20) : 14074-8.
  • Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases. Specificity and kinetics.

    Bialojan C et al (1988) Biochem J 256(1) : 283-90.

4 Item(s)

Publications
These publications cite the use of Okadaic Acid purchased from Hello Bio:
  • PP2A protects podocytes against Adriamycin-induced injury and epithelial-to-mesenchymal transition via suppressing JIP4/p38-MAPK pathway

    Lu Z et al (2021) Cytotechnology 73(5) : 697-713
    PubMedID: 34629746

1 Item