Okadaic Acid

Name: Okadaic Acid
Brand: Hello Bio
SKU: HB0468
Price: 112 USD
Availability: InStock

(HB0468)

Publications (1)

Technical documents: SDS CoA Datasheet

Product overview

Name

Okadaic Acid

Alternative names

Purity

>98%

Description

Potent, non-competitive protein phosphatase inhibitor

Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Publications (1) References (4) Frequently bought together

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Images

Okadaic Acid product vial image | Hello Bio

Biological Data

Biological description

Potent and non-competitive protein phosphatase inhibitor. Exhibits higher selectivity for PP2A and PP1 over PCM (purified polycation-modulated) phosphatase and PP2B (ID₅₀ values are 1.2, 315, 205 and 4530 nM respectively) yet little or no activity at PP2C. Displays apoptosis inducing properties with neurotoxic and tumor promoting effects. A diarrheic shellfish poisoning (DSP) toxin.

Solubility & Handling

Storage instructions

-20°C (desiccate)

Solubility overview

Soluble in DMSO (100mM)

Important

This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

More Info

Dilution

More Info

Chemical Data

Purity

>98%

Chemical name

9,10-Deepithio-9,10-didehydroacanthifolicin

Molecular Weight

805.01

Chemical structure

Molecular Formula

C₄₄H₆₈O₁₃

CAS Number

78111-17-8

PubChem identifier

446512

SMILES

C[C@@H]1CC[C@]2(CCCCO2)O[C@@H]1[C@@H](C)C[C@@H]([C@@H]3C(=C)[C@H]([C@H]4[C@H](O3)CC[C@]5(O4)CC[C@@H](O5)/C=C/[C@@H](C)[C@@H]6CC(=C[C@@]7(O6)[C@@H](CC[C@H](O7)C[C@](C)(C(=O)O)O)O)C)O)O

InChi

InChI=1S/C44H68O13/c1-25-21-34(55-44(23-25)35(46)12-11-31(54-44)24-41(6,50)40(48)49)26(2)9-10-30-14-18-43(53-30)19-15-33-39(57-43)36(47)29(5)38(52-33)32(45)22-28(4)37-27(3)13-17-42(56-37)16-7-8-20-51-42/h9-10,23,26-28,30-39,45-47,50H,5,7-8,11-22,24H2,1-4,

InChiKey

QNDVLZJODHBUFM-WFXQOWMNSA-N

MDL number

MFCD00083455

Technical guides

Understanding purity and quality - a guide for life scientists (159.4 KB)

References for Okadaic Acid

References are publications that support the biological activity of the product

Okadaic acid: more than a diarrheic toxin.
Valdiglesias V et al (2013) Mar Drugs 11(11) : 4328-49.
Read more (PubMedID: 24184795)
Okadaic acid activates the PKR pathway and induces apoptosis through PKR stimulation in MG63 osteoblast-like cells.
Haneji T et al (2013) Int J Oncol 42(6) : 1904-10.
Read more (PubMedID: 23591640)
Okadaic acid activates atypical protein kinase C (zeta/lambda) in rat and 3T3/L1 adipocytes. An apparent requirement for activation of Glut4 translocation and glucose transport.
Standaert ML et al (1999) J Biol Chem 274(20) : 14074-8.
Read more (PubMedID: 10318822)
Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases. Specificity and kinetics.
Bialojan C et al (1988) Biochem J 256(1) : 283-90.
Read more (PubMedID: 2851982)

Publications

Submit Yours Now

These publications cite the use of Okadaic Acid purchased from Hello Bio:

PP2A protects podocytes against Adriamycin-induced injury and epithelial-to-mesenchymal transition via suppressing JIP4/p38-MAPK pathway
Lu Z et al (2021) Cytotechnology 73(5) : 697-713
PubMedID: 34629746

Grouped product items
Order: HB0468
Pack	Price	Qty
25μg	$112
50μg	$162
100μg	$257

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Potent, non-competitive protein phosphatase inhibitor

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Okadaic Acid

Product overview

Images

Biological Data

Solubility & Handling

Calculators

Molarity

Dilution

Chemical Data

Technical guides

References for Okadaic Acid

Okadaic acid: more than a diarrheic toxin.

Okadaic acid activates the PKR pathway and induces apoptosis through PKR stimulation in MG63 osteoblast-like cells.

Okadaic acid activates atypical protein kinase C (zeta/lambda) in rat and 3T3/L1 adipocytes. An apparent requirement for activation of Glut4 translocation and glucose transport.

Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases. Specificity and kinetics.

PP2A protects podocytes against Adriamycin-induced injury and epithelial-to-mesenchymal transition via suppressing JIP4/p38-MAPK pathway

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Okadaic Acid

Product overview

Images

Okadaic Acid product vial image | Hello Bio

Biological Data

Solubility & Handling

Calculators

Molarity

Dilution

Chemical Data

Technical guides

References for Okadaic Acid

Okadaic acid: more than a diarrheic toxin.

Okadaic acid activates the PKR pathway and induces apoptosis through PKR stimulation in MG63 osteoblast-like cells.

Okadaic acid activates atypical protein kinase C (zeta/lambda) in rat and 3T3/L1 adipocytes. An apparent requirement for activation of Glut4 translocation and glucose transport.

Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases. Specificity and kinetics.

PP2A protects podocytes against Adriamycin-induced injury and epithelial-to-mesenchymal transition via suppressing JIP4/p38-MAPK pathway

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Tell us about your publication!

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