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Okadaic Acid

(HB0468)
Publications (1)
Technical documents: SDS CoA Datasheet
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Product overview

Name Okadaic Acid
Alternative names OA
Purity >98%
Description Potent, non-competitive protein phosphatase inhibitor
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews Publications (1) References (4) Frequently bought together
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Okadaic Acid product vial image | Hello Bio
Okadaic Acid product vial image | Hello Bio

Okadaic Acid product vial image | Hello Bio

Okadaic Acid product vial image | Hello Bio

Biological Data

Biological description Potent and non-competitive protein phosphatase inhibitor. Exhibits higher selectivity for PP2A and PP1 over PCM (purified polycation-modulated) phosphatase and PP2B (ID50 values are 1.2, 315, 205 and 4530 nM respectively) yet little or no activity at PP2C. Displays apoptosis inducing properties with neurotoxic and tumor promoting effects. A diarrheic shellfish poisoning (DSP) toxin.

Solubility & Handling

Solubility overview Soluble in DMSO (100mM)
Storage instructions -20°C (desiccate)
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name 9,10-Deepithio-9,10-didehydroacanthifolicin
Molecular Weight 805.01
Chemical structure Okadaic Acid [78111-17-8] Chemical Structure
Molecular Formula C44H68O13
CAS Number 78111-17-8
PubChem identifier 446512
SMILES C[C@@H]1CC[C@]2(CCCCO2)O[C@@H]1[C@@H](C)C[C@@H]([C@@H]3C(=C)[C@H]([C@H]4[C@H](O3)CC[C@]5(O4)CC[C@@H](O5)/C=C/[C@@H](C)[C@@H]6CC(=C[C@@]7(O6)[C@@H](CC[C@H](O7)C[C@](C)(C(=O)O)O)O)C)O)O
InChi InChI=1S/C44H68O13/c1-25-21-34(55-44(23-25)35(46)12-11-31(54-44)24-41(6,50)40(48)49)26(2)9-10-30-14-18-43(53-30)19-15-33-39(57-43)36(47)29(5)38(52-33)32(45)22-28(4)37-27(3)13-17-42(56-37)16-7-8-20-51-42/h9-10,23,26-28,30-39,45-47,50H,5,7-8,11-22,24H2,1-4,
InChiKey QNDVLZJODHBUFM-WFXQOWMNSA-N
MDL number MFCD00083455

References for Okadaic Acid

References are publications that support the biological activity of the product

  • Okadaic acid: more than a diarrheic toxin.

    Valdiglesias V et al (2013) Mar Drugs 11(11) : 4328-49.
    Read more (PubMedID: 24184795)

  • Okadaic acid activates the PKR pathway and induces apoptosis through PKR stimulation in MG63 osteoblast-like cells.

    Haneji T et al (2013) Int J Oncol 42(6) : 1904-10.
    Read more (PubMedID: 23591640)

  • Okadaic acid activates atypical protein kinase C (zeta/lambda) in rat and 3T3/L1 adipocytes. An apparent requirement for activation of Glut4 translocation and glucose transport.

    Standaert ML et al (1999) J Biol Chem 274(20) : 14074-8.
    Read more (PubMedID: 10318822)

  • Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases. Specificity and kinetics.

    Bialojan C et al (1988) Biochem J 256(1) : 283-90.
    Read more (PubMedID: 2851982)

4 Item(s)

Publications
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These publications cite the use of Okadaic Acid purchased from Hello Bio:

  • PP2A protects podocytes against Adriamycin-induced injury and epithelial-to-mesenchymal transition via suppressing JIP4/p38-MAPK pathway

    Lu Z et al (2021) Cytotechnology 73(5) : 697-713
    PubMedID: 34629746

1 Item

Related Products
Grouped product items
Order: HB0468
Pack PriceQty
25μg
$117
50μg
$169
100μg
$268
Potent, non-competitive protein phosphatase inhibitor
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

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