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NSC 74859

(HB1436)
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Product overview

Name NSC 74859
Alternative names S3I-201
Purity >98%
Description Selective STAT3 inhibitor
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (3) Frequently bought together
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Biological Data

Biological description Selective STAT3 DNA-binding inhibitor. Selectively inhibits STAT3-STAT3 over STAT1-STAT3 and STAT1-STAT1 DNA-binding (IC50 values are 86, 160 and >300 µM respectively). Enhances the activity of cytotoxic drugs. Shows antiproliferative, apoptotic and anti-tumor actions.

Solubility & Handling

Solubility overview Soluble in DMSO (10mM)
Storage instructions -20°C
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name 2-Hydroxy-4-[[2-[[(4-methylphenyl)sulfonyl]oxy]acetyl]amino]benzoic acid
Molecular Weight 365.36
Chemical structure NSC 74859 [501919-59-1] Chemical Structure
Molecular Formula C16H15NO7S
CAS Number 501919-59-1
PubChem identifier 252682
SMILES CC1=CC=C(S(OCC(NC2=CC=C(C(O)=O)C(O)=C2)=O)(=O)=O)C=C1
InChiKey HWNUSGNZBAISFM-UHFFFAOYSA-N

References for NSC 74859

References are publications that support the biological activity of the product

  • NSC 74859-mediated inhibition of STAT3 enhances the anti-proliferative activity of cetuximab in hepatocellular carcinoma.

    Chen W et al (2012) Liver Int 32(1) : 70-7.
    Read more (PubMedID: 22098470)

  • NSC 74859 enhances doxorubicin cytotoxicity via inhibition of epithelial-mesenchymal transition in hepatocellular carcinoma cells.

    Hu QD et al (2012) Cancer Lett 325(2) : 207-13.
    Read more (PubMedID: 22781398)

  • Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity.

    Siddiquee K et al (2007) Proc Natl Acad Sci U S A 104(18) : 7391-6.
    Read more (PubMedID: 17463090)

3 Item(s)

Grouped product items
Order: HB1436
Pack PriceQty
5mg
$115
25mg
$460
Selective STAT3 inhibitor
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

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