±-Octopamine hydrochloride

Technical documents: CoA Datasheet

Product overview

Name ±-Octopamine hydrochloride
Alternative names Epirenor, Norfen
Purity >99%
Description Invertebrate neurotransmitter. Chemogenetic DmOctβ1 receptor activator.
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Biological Data

Biological description

Invertebrate neurotransmitter which is structurally related to noradrenaline. Acts as a neurohormone, neuromodulator and neurotransmitter in invertebrates. Gαs-coupled DmOctβ1 receptor (EC50 value = ~12 nM at DmOctβ1R). Shown to activate the chemogenetic Gαs-coupled DmOctβ1 receptor in mouse excitatory neurons of the hippocampus to elevate cAMP levels in tissue expressing the receptor. This approach has been shown to make animals resilient to memory deficits normally caused by sleep loss and to render hippocampal synaptic plasticity resilient to sleep deprivation.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in water (100 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use



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Chemical Data

Purity >99%
Chemical name (±)-2-Amino-1-(4-hydroxyphenyl)ethanol hydrochloride
Molecular Weight 189.6
Chemical structure  Chemical Structure
Molecular Formula C8H11NO2.HCl
CAS Number 770-05-8
PubChem identifier 102484
InChi InChI=1S/C8H11NO2.ClH/c9-5-8(11)6-1-3-7(10)4-2-6;/h1-4,8,10-11H,5,9H2;1H
MDL number MFCD00012881

References for ±-Octopamine hydrochloride

References are publications that support the biological activity of the product
  • Chemogenetic Enhancement of cAMP Signaling Renders Hippocampal Synaptic Plasticity Resilient to the Impact of Acute Sleep Deprivation.

    Walsh EN et al (2023) eNeuro 10 :
  • Octopamine in invertebrates.

    Roeder T (1999) Progress in neurobiology 59 : 533-61
  • Selective inhibition of adenylyl cyclase by octopamine via a human cloned alpha 2A-adrenoceptor.

    Airriess CN et al (1997) British journal of pharmacology 122 : 191-8

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