GluN2C

Potent mGlu₄ positive allosteric modulator

mGlu₄ positive allosteric modulator

Potent mGlu₅ positive allosteric modulator

Endogenous group II mGlu agonist

K_ir3.4 channel activator

Guanylyl cyclase activator. Also induces G1 cell cycle arrest.

Selective PIEZO1 channel activator

Novel, selective Piezo1 channel activator. Improved efficacy, potency and solubility compared to Yoda1.

Estrogen receptor agonist

Potent 5-HT_1B/1D/1F agonist