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Biological Data Biological description Kir 3.4 (ATP-sensitive K+ ) channel activator (IC50 = 27 µM). Inhibits noradrenaline-activated Ca2+ release and Ca2+ influx. Displays vasodilating and cardioprotective properties.
Solubility & Handling Storage instructions Room temperature
Solubility overview Soluble in NaOH(aq) (100mM, 1eq. NaOH)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use
Chemical Data Chemical name N -[(3S ,4R )-6-Cyano-3,4-dihydro-3-hy droxy-2,2-dimethyl-2H -1-benzopyran-4-yl]-N -hydroxy acetamide
Chemical structure
Molecular Formula C14 H16 N2 O4
PubChem identifier 121878
SMILES CC(=O)N(O)[C@H]1[C@H](O)C(C)(C)OC2=C1C=C(C=C2)C#N
InChi InChI=1S/C14H16N2O4/c1-8(17)16(19)12-10-6-9(7-15)4-5-11(10)20-14(2,3)13(12)18/h4-6,12-13,18-19H,1-3H3/t12-,13+/m1/s1
InChiKey IWTCFIIOUXJOOV-OLZOCXBDSA-N
References for Y-26763 References are publications that support the biological activity of the product
Y-26763: ATP-sensitive K+ channel activation and the inhibition of insulin release from human pancreatic beta-cells. Cosgrove KE et al (2004) Eur J Pharmacol 486(2) : 133-9. Effects of a newly synthesized K+ channel opener, Y-26763, on noradrenaline-induced Ca2+ mobilization in smooth muscle of the rabbit mesenteric artery. Itoh T et al (1994) Br J Pharmacol 111(1) : 165-72. Y-27152, a long-acting K+ channel opener with less tachycardia: antihypertensive effects in hypertensive rats and dogs in conscious state. Nakajima T et al (1992) J Pharmacol Exp Ther 261(2) : 730-6.
![Y-26763 [127408-31-5] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb1098.png "Y-26763 [127408-31-5]")
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