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Mitomycin C

(HB4458)
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Product overview

Name Mitomycin C
Alternative names Ametycine, MMC, NSC 26980
Purity >97%
Description Antibiotic. DNA synthesis inhibitor.
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (2) Reviews References (3) Frequently bought together
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Biological Data

Biological description

Inhibits proliferation of various cell types. Inhibits DNA synthesis by forming covalent crosslinks between complementary DNA strands.


Widely used for treatment of feeder cell layers (e.g. for PMEF (primary mouse embryonic fibroblasts) and CD1 mouse embryonic fibroblasts (MEFs) and hESCs (human embryonic stem cells).


Also shows antitumor activity.

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in DMSO (100 mM) and water (5 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >97%
Chemical name [1aS-(1aα,8β,8aα,8bα)]-6-Amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methylazirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione
Molecular Weight 334.33
Molecular Formula C15H18N4O5
CAS Number 50-07-7
PubChem identifier 5746
SMILES CC1=C(C(=O)C2=C(C1=O)N3C[C@H]4[C@@H]([C@@]3([C@@H]2COC(=O)N)OC)N4)N
InChiKey NWIBSHFKIJFRCO-WUDYKRTCSA-N
MDL number MFCD00078109
Appearance Purple

References for Mitomycin C

References are publications that support the biological activity of the product

  • Mitomycin C as an alternative to irradiation to inhibit the feeder layer growth in long-term culture assays.

    Ponchio et al (2000) Cytotherapy 2(4) : 281-6
    Read more (PubMedID: 12042037)

  • Isolation and structure of an intrastrand cross-link adduct of mitomycin C and DNA.

    Bizanek et al (1992) Biochemistry 31(12) : 3084-19
    Read more (PubMedID: 1554696)

  • Isolation and structure of a covalent cross-link adduct between mitomycin C and DNA.

    Tomasz et al (1987) Science 235(4793) : 1204-8
    Read more (PubMedID: 3103215)

3 Item(s)

Grouped product items
Order: HB4458
Pack PriceQty
5mg
$75
25mg
$290
Antibiotic. DNA synthesis inhibitor.
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

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