LY 294002 hydrochloride
(HB2266)
Product overview
| Name | LY 294002 hydrochloride |
| Description | PI3-K inhibitor. Suppresses mESC proliferation. |
| Biological description | LY 294002 hydrochloride is a competitive and reversible PI3-Kinase inhibitor (IC50 values are 0.5, 0.6, 0.3 and 3.8 µM at p110α (PI3-Kα), p110β (PI3-Kβ), p110δ (PI3-Kδ) and p110γ (PI3-Kγ) respectively). It also shows activity at a range of other PI3-K related kinases and other targets.
|
| Alternative names | TGX-115, PIK-108 |
| Purity | >99% |
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Solubility & Handling
| Storage instructions | Room temperature |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | 2-(4-Morpholinyl)-8-phenyl-4H-1-ben zopyran-4-one hydrochloride |
| Molecular Weight | 343.81 |
| Chemical structure |  |
| Molecular Formula | C19H17NO3.HCl |
| CAS Number | 934389-88-5 |
| PubChem identifier | 11957589 |
| SMILES | Cl.O=C1C=C(OC2=C1C=CC=C2C1=CC=CC=C1)N1CCOCC1 |
| InChiKey | OQZQSRICUOWBLW-UHFFFAOYSA-N |
References for LY 294002 hydrochloride
References are publications that support the biological activity of the product
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A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).
Viahos et al (1994) J Biol Chem 269(7) : 5241-8 -
Phosphoinositide 3-kinase inhibitor LY294002 but not serum withdrawal suppresses proliferation of murine embryonic stem cells.
Lianguzova et al (2007) Cell Biol Int 31(4) : 330-7 -
The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes.
Biommaart et al (1997) Eur J Biochem 243(1-2) : 240-6
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