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LY 294002 hydrochloride

(HB2266)
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Product overview

Name LY 294002 hydrochloride
Alternative names TGX-115, PIK-108
Purity >99%
Description PI3-K inhibitor. Suppresses mESC proliferation.
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (2) Reviews References (3) Frequently bought together
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Biological Data

Biological description

LY 294002 hydrochloride is a competitive and reversible PI3-Kinase inhibitor (IC50 values are 0.5, 0.6, 0.3 and 3.8 µM at p110α (PI3-Kα), p110β (PI3-Kβ), p110δ (PI3-Kδ) and p110γ (PI3-Kγ) respectively). It also shows activity at a range of other PI3-K related kinases and other targets.


LY 294002 additionally inhibits growth of many tumor types and induces apoptosis. It also suppresses proliferation of mESCs (mouse embryonic stem cells).

Solubility & Handling

Storage instructions Room temperature
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >99%
Chemical name 2-(4-Morpholinyl)-8-phenyl-4H-1-ben zopyran-4-one hydrochloride
Molecular Weight 343.81
Chemical structure LY 294002 hydrochloride Chemical Structure
Molecular Formula C19H17NO3.HCl
CAS Number 934389-88-5
PubChem identifier 11957589
SMILES Cl.O=C1C=C(OC2=C1C=CC=C2C1=CC=CC=C1)N1CCOCC1
InChiKey OQZQSRICUOWBLW-UHFFFAOYSA-N

References for LY 294002 hydrochloride

References are publications that support the biological activity of the product

  • Phosphoinositide 3-kinase inhibitor LY294002 but not serum withdrawal suppresses proliferation of murine embryonic stem cells.

    Lianguzova et al (2007) Cell Biol Int 31(4) : 330-7
    Read more (PubMedID: 17321171)

  • The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes.

    Biommaart et al (1997) Eur J Biochem 243(1-2) : 240-6
    Read more (PubMedID: 9030745)

  • A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).

    Viahos et al (1994) J Biol Chem 269(7) : 5241-8
    Read more (PubMedID: 8106507)

3 Item(s)

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Order: HB2266
Pack PriceQty
5mg
$55
25mg
$176
PI3-K inhibitor. Suppresses mESC proliferation.
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