LY 294002 hydrochloride is a competitive and reversible PI3-Kinase inhibitor (IC50 values are 0.5, 0.6, 0.3 and 3.8 µM at p110α (PI3-Kα), p110β (PI3-Kβ), p110δ (PI3-Kδ) and p110γ (PI3-Kγ) respectively). It also shows activity at a range of other PI3-K related kinases and other targets.
LY 294002 additionally inhibits growth of many tumor types and induces apoptosis. It also suppresses proliferation of mESCs (mouse embryonic stem cells).
Solubility & Handling
Storage instructions
Room temperature
Storage of solutions
Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions
Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Y-27632 is a selective ROCK inhibitor. Frequently used 3D growth matrix component and for production of organoids. Also used when inducing neurons from fibroblasts. Manufactured to a high degree of optical purity.
Understanding purity and quality - a guide for life scientists
