Product overview

Name LY 294002 hydrochloride
Description PI3-K inhibitor. Suppresses mESC proliferation.
Biological description

LY 294002 hydrochloride is a competitive and reversible PI3-Kinase inhibitor (IC50 values are 0.5, 0.6, 0.3 and 3.8 µM at p110α (PI3-Kα), p110β (PI3-Kβ), p110δ (PI3-Kδ) and p110γ (PI3-Kγ) respectively). It also shows activity at a range of other PI3-K related kinases and other targets.


LY 294002 additionally inhibits growth of many tumor types and induces apoptosis. It also suppresses proliferation of mESCs (mouse embryonic stem cells).

Alternative names TGX-115, PIK-108
Purity >99%
Write Your Own Review
You're reviewing:LY 294002 hydrochloride
Rate this item:

Solubility & Handling

Storage instructions Room temperature
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

=
x
x
More Info

Dilution

x
=
x
More Info

Chemical Data

Chemical name 2-(4-Morpholinyl)-8-phenyl-4H-1-ben zopyran-4-one hydrochloride
Molecular Weight 343.81
Chemical structure Product image
Molecular Formula C19H17NO3.HCl
CAS Number 934389-88-5
PubChem identifier 11957589
SMILES Cl.O=C1C=C(OC2=C1C=CC=C2C1=CC=CC=C1)N1CCOCC1
InChiKey OQZQSRICUOWBLW-UHFFFAOYSA-N

References for LY 294002 hydrochloride

References are publications that support the biological activity of the product
  • A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).

    Viahos et al (1994) J Biol Chem 269(7) : 5241-8
  • Phosphoinositide 3-kinase inhibitor LY294002 but not serum withdrawal suppresses proliferation of murine embryonic stem cells.

    Lianguzova et al (2007) Cell Biol Int 31(4) : 330-7
  • The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes.

    Biommaart et al (1997) Eur J Biochem 243(1-2) : 240-6