DREADDs

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Designer receptors exclusively activated by designer drugs (DREADDs) are genetically engineered GPCRs that are activated by physiologically inert synthetic small molecules (designer drugs) but not their endogenous ligand. Read our DREADDs mini-review or for practical advice on using these ligands in the lab see Stability of Water-Soluble DREADD Ligands in Solution: A Technical Review and Clozapine N-Oxide (freebase) - a technical review on stability, solubility and use in the lab).

Items 1-10 of 240

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  1. 2  Reviews
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    Description:

    Neurotoxin, widely used to produce the 6-OHDA Parkinson’s disease model

    Purity:

    >98%

    Pack:
    50mg
    Price:
    $55
    Qty:
    Pack:
    250mg
    Price:
    $104
    Qty:
    Pack:
    1g
    Price:
    $349
    Qty:
  2. A 83-01 (HB3218)

    1  Review
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    Description:

    Selective TGF-βRI (ALK5), ALK4 and ALK7 inhibitor. Maintains human hiPSC self renewal, 3D growth matrix component and promotes long-term organoid growth. Aids fibroblast to NSC/cardiomyocyte reprogramming.

    Purity:

    >98%

    Pack:
    5mg
    Price:
    $80
    Qty:
    Pack:
    25mg
    Price:
    $270
    Qty:
  3. Description:

    Potent dopamine D4 receptor partial agonist

    Purity:

    >99%

    Pack:
    50mg
    Price:
    $568
    Qty:
  4. Pack:
    10mg
    Price:
    $243
    Qty:
    Pack:
    50mg
    Price:
    $917
    Qty:
  5. AM251 (HB2776)

    3  Reviews
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    Description:

    Potent, selective CB1 receptor antagonist / inverse agonist

    Purity:

    >98%

    Pack:
    1mg
    Price:
    $56
    Qty:
    Pack:
    10mg
    Price:
    $124
    Qty:
    Pack:
    50mg
    Price:
    $476
    Qty:
  6. Pack:
    10mg
    Price:
    $152
    Qty:
    Pack:
    50mg
    Price:
    $626
    Qty:
  7. L-AP4 (HB0370)

    3  Reviews
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    Description:

    L-AP4 is a selective group III mGluR agonist which inhibits synaptic transmission.

    Purity:

    >99%

    Pack:
    5mg
    Price:
    $74
    Qty:
    Pack:
    10mg
    Price:
    $143
    Qty:
    Pack:
    25mg
    Price:
    $298
    Qty:
    Pack:
    50mg
    Price:
    $592
    Qty:
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