6-Hydroxydopamine (6-OHDA) hydrobromide

(HB1889)
Technical documents: SDS CoA Datasheet

Product overview

Name 6-Hydroxydopamine (6-OHDA) hydrobromide
Description Neurotoxin, widely used to produce the 6-OHDA Parkinson’s disease model
Biological description

6-hydroxydopamine hydrobromide (6-OHDA) is widely used to lesion the nigrostriatal dopaminergic system as a model of Parkinson’s disease (6-OHDA lesion model).


6-OHDA is commonly unilaterally administered into the medial forebrain bundle (MFB), substantia nigra or striatum to induce a selective depletion of dopamine neurons to reproduce behavioural deficits seen in Parkinson’s disease. Varying degrees of neurodegeneration occur depending on site of administration.


Unilateral administration of 6-OHDA into one hemisphere (hemiparkinsonian model) permits assessment of a quantifiable turning behaviour which can be correlated with the magnitude of the nigrostriatal lesions. Bilateral 6-OHDA lesion models may also be used.

Alternative names 6-OHDA, Oxidopamine
Purity >98%
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Solubility & Handling

Storage instructions Room temperature (desiccate)
Solubility overview Soluble in water (100 mM) and in DMSO (100 mM)
Handling This compound is air sensitive; exposure to air may affect compound performance. We therefore recommend storing the material in a sealed jar. Do not store the material in solution; make up solutions and use immediately.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

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Chemical Data

Chemical name 5-(2-Aminoethyl)-1,2,4-benzenetriol hydrobromide
Molecular Weight 250.09
Chemical structure Product image
Molecular Formula C8H11NO3 · HBr
CAS Number 636-00-0
PubChem identifier 176170
SMILES C1=C(C(=CC(=C1O)O)O)CCN.Br
InChi InChI=1S/C8H11NO3.BrH/c9-2-1-5-3-7(11)8(12)4-6(5)10;/h3-4,10-12H,1-2,9H2;1H
InChiKey MLACDGUOKDOLGC-UHFFFAOYSA-N
MDL number MFCD00012894
Appearance Off-white to brown solid

References for 6-Hydroxydopamine (6-OHDA) hydrobromide

References are publications that support the biological activity of the product
  • A guide to neurotoxic animal models of Parkinson's disease.

    Tieu K (2011) Cold Spring Harb Perspect Med 1(1) : a009316
  • Unilateral Lesion of Dopamine Neurons Induces Grooming Asymmetry in the Mouse.

    Pelosi et al (2015) PLoS One 10(9) : e137185
  • Limitations of animal models of Parkinson's disease.

    Potashkin et al (2010) Parkinsons Dis 2011:658083 : 20
  • Behavioral characterization of a unilateral 6-OHDA-lesion model of Parkinson's disease in mice.

    Iancu et al (2005) Behav Brain Res. 162(1) : 1-10
Publications
These publications cite the use of 6-Hydroxydopamine (6-OHDA) hydrobromide purchased from Hello Bio:
  • Loss of Collapsin Response Mediator Protein 4 Attenuates 6-Hydroxydopamine-Induced Impairments in a Mouse Model of Parkinson's Disease

    Li et al (2020) Neurochem Res. : doi: 10.1007/s11064-020-03086-z
    PubMedID: 32648145

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