6-Hydroxydopamine (6-OHDA) hydrobromide
(HB1889)
Product overview
| Name | 6-Hydroxydopamine (6-OHDA) hydrobromide |
| Description | Neurotoxin, widely used to produce the 6-OHDA Parkinson’s disease model |
| Biological description | 6-hydroxydopamine hydrobromide (6-OHDA) is widely used to lesion the nigrostriatal dopaminergic system as a model of Parkinson’s disease (6-OHDA lesion model).
|
| Alternative names | 6-OHDA, Oxidopamine |
| Purity | >98% |
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Solubility & Handling
| Storage instructions | Room temperature (desiccate) |
| Solubility overview | Soluble in water (100 mM) and in DMSO (100 mM) |
| Handling | This compound is air sensitive; exposure to air may affect compound performance. We therefore recommend storing the material in a sealed jar. Do not store the material in solution; make up solutions and use immediately. |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use |
Chemical Data
| Chemical name | 5-(2-Aminoethyl)-1,2,4-benzenetriol hydrobromide |
| Molecular Weight | 250.09 |
| Chemical structure |  |
| Molecular Formula | C8H11NO3 · HBr |
| CAS Number | 636-00-0 |
| PubChem identifier | 176170 |
| SMILES | C1=C(C(=CC(=C1O)O)O)CCN.Br |
| InChi | InChI=1S/C8H11NO3.BrH/c9-2-1-5-3-7(11)8(12)4-6(5)10;/h3-4,10-12H,1-2,9H2;1H |
| InChiKey | MLACDGUOKDOLGC-UHFFFAOYSA-N |
| MDL number | MFCD00012894 |
| Appearance | Off-white to brown solid |
References for 6-Hydroxydopamine (6-OHDA) hydrobromide
References are publications that support the biological activity of the product
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A guide to neurotoxic animal models of Parkinson's disease.
Tieu K (2011) Cold Spring Harb Perspect Med 1(1) : a009316 -
Unilateral Lesion of Dopamine Neurons Induces Grooming Asymmetry in the Mouse.
Pelosi et al (2015) PLoS One 10(9) : e137185 -
Limitations of animal models of Parkinson's disease.
Potashkin et al (2010) Parkinsons Dis 2011:658083 : 20 -
Behavioral characterization of a unilateral 6-OHDA-lesion model of Parkinson's disease in mice.
Iancu et al (2005) Behav Brain Res. 162(1) : 1-10
Publications
These publications cite the use of 6-Hydroxydopamine (6-OHDA) hydrobromide purchased from Hello Bio:
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Loss of Collapsin Response Mediator Protein 4 Attenuates 6-Hydroxydopamine-Induced Impairments in a Mouse Model of Parkinson's Disease
Li et al (2020) Neurochem Res. : doi: 10.1007/s11064-020-03086-zPubMedID: 32648145
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