6-Hydroxydopamine (6-OHDA) hydrobromide
Product overview
Name | 6-Hydroxydopamine (6-OHDA) hydrobromide |
Description | Neurotoxin, widely used to produce the 6-OHDA Parkinson’s disease model |
Alternative names | 6-OHDA, Oxidopamine |
Purity | >98% |
Biological Data
Biological description | 6-hydroxydopamine hydrobromide (6-OHDA) is widely used to lesion the nigrostriatal dopaminergic system as a model of Parkinson’s disease (6-OHDA lesion model).
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Solubility & Handling
Storage instructions | -20°C |
Solubility overview | Soluble in water (100 mM) and in DMSO (100 mM) |
Handling | This compound is very air and light sensitive; exposure to air/light may affect compound performance. We therefore recommend storing the solid material at -20°C in a sealed jar, in the dark and protect from light. As the compound is hygroscopic, dessicate if possible. Do not store the material in solution; make up solutions and use immediately. Protect from light. Solutions can be prepared using oxygen free water containing 0.1% sodium metabisulfite. |
Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use |
Chemical Data
Chemical name | 5-(2-Aminoethyl)-1,2,4-benzenetriol hydrobromide |
Molecular Weight | 250.09 |
Chemical structure | |
Molecular Formula | C8H11NO3 · HBr |
CAS Number | 636-00-0 |
PubChem identifier | 176170 |
SMILES | C1=C(C(=CC(=C1O)O)O)CCN.Br |
InChi | InChI=1S/C8H11NO3.BrH/c9-2-1-5-3-7(11)8(12)4-6(5)10;/h3-4,10-12H,1-2,9H2;1H |
InChiKey | MLACDGUOKDOLGC-UHFFFAOYSA-N |
MDL number | MFCD00012894 |
Appearance | Off-white to brown solid |
References for 6-Hydroxydopamine (6-OHDA) hydrobromide
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Unilateral Lesion of Dopamine Neurons Induces Grooming Asymmetry in the Mouse.
Pelosi et al (2015) PLoS One 10(9) : e137185 -
A guide to neurotoxic animal models of Parkinson's disease.
Tieu K (2011) Cold Spring Harb Perspect Med 1(1) : a009316 -
Limitations of animal models of Parkinson's disease.
Potashkin et al (2010) Parkinsons Dis 2011:658083 : 20 -
Behavioral characterization of a unilateral 6-OHDA-lesion model of Parkinson's disease in mice.
Iancu et al (2005) Behav Brain Res. 162(1) : 1-10
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Loss of Collapsin Response Mediator Protein 4 Attenuates 6-Hydroxydopamine-Induced Impairments in a Mouse Model of Parkinson's Disease
Li et al (2020) Neurochem Res. : doi: 10.1007/s11064-020-03086-zPubMedID: 32648145