Product overview

Name Acamprosate calcium
Description GABA receptor agonist and glutamatergic modulator
Alternative names Calcium acetylhomotaurinate | Campral
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Biological Data

Biological description GABA receptor agonist. Also acts as NMDA receptor and mGluR5 antagonist. Taurinate analog. Reduces alcohol addiction in various animal models. Displays neuroprotective properties.

Solubility & Handling

Storage instructions Room temperature (desiccate)
Solubility overview Soluble in water (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Chemical Data

Chemical name 3-(Acetylamino)-1-propanesulfonic acid hemicalcium salt
Molecular Weight 200.24
Chemical structure Acamprosate calcium  [77337-73-6] Chemical Structure
Molecular Formula C5H10NO4S.½ Ca
CAS Number 77337-73-6
PubChem identifier 155434
SMILES CC(=O)NCCCS(=O)(=O)[O-].CC(=O)NCCCS(=O)(=O)[O-].[Ca+2]
InChiKey BUVGWDNTAWHSKI-UHFFFAOYSA-L

References for Acamprosate calcium

References are publications that support the biological activity of the product
  • Neuroprotective and abstinence-promoting effects of acamprosate: elucidating the mechanism of action.

    De Witte P et al (2005) CNS Drugs 19(6) : 517-37.
  • Acamprosate enhances N-methyl-D-apartate receptor-mediated neurotransmission but inhibits presynaptic GABA(B) receptors in nucleus accumbens neurons.

    Berton F et al (1998) Alcohol Clin Exp Res 22(1) : 183-91.