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[Ala11,D-Leu15]-Orexin B

(HB3407)
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Product overview

Name [Ala11,D-Leu15]-Orexin B
Biological description Highly potent and selective OX2receptor agonist which displays 400-fold selectivity over OX1 receptors (EC50 values are 0.13 and 52 nM for human OX2receptor and OX1receptor receptors respectively).
Purity >95%
Description Potent, selective OX2 receptor agonist
Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (3) Frequently bought together
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Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in water (0.3 mg/ml)
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

Molarity

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Dilution

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Chemical Data

Purity >95%
Chemical name RSGPPGLQGRAQRLLQASGNHAAGILTM (modifications: Met-28 = C-terminal amide)
Molecular Weight 2857.28
Chemical structure [Ala11,D-Leu15]-Orexin B | [532932-99-3] Chemical Structure
Molecular Formula C120H206N44O35S
Sequence (one letter) RSGPPGLQGRAQRLLQASGNHAAGILTM
Modifications Met-28 = C-terminal amide
CAS Number 532932-99-3
PubChem identifier 90473850
SMILES CC[C@H](C)[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCSC)C(=O)N)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC1=CNC=N1)NC(=O)[C@H](CC(=O)N)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H]2CCCN2C(=O)[C@@H]3CCCN3C(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(=N)N)N
InChiKey SURUUKNICBOUOQ-UBNRXWOCSA-N

References for [Ala11,D-Leu15]-Orexin B

References are publications that support the biological activity of the product

  • Orexins/hypocretins acting at Gi protein-coupled OX 2 receptors inhibit cyclic AMP synthesis in the primary neuronal cultures.

    Urbanska et al (2012) J Mol Neurosci 46(1) : 10-7
    Read more (PubMedID: 21547533)

  • Orexin directly excites orexin neurons through orexin 2 receptor.

    Yamanaka (2010) J Neurosci 30(38) : 12642-52
    Read more (PubMedID: 20861370)

  • Development of an orexin-2 receptor selective agonist, [Ala(11), D-Leu(15)]orexin-B.

    Asahi et al (2003) Bioorg Med Chem Lett 13(1) : 111-3
    Read more (PubMedID: 12467628)

3 Item(s)

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Order: HB3407
Pack PriceQty
1mg
$283
Potent, selective OX2 receptor agonist
Shipping Info

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Hazardous: $35

Shipped on ice: $35

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