Agonists & activators
An agonist or activator, is a drug or chemical that binds to and activates a protein, such as receptor or enzyme. Full agonists have high efficacy, eliciting a full response whilst occupying a small proportion of receptors. Partial agonists have a lower efficacy and cannot produce a maximal response, even if occupying a high proportion of receptors. Inverse agonists can bind to the same receptor binding-site as an agonist, but elicit an opposite effect. Researchers can save up to 50% on activators, agonists, partial agonists and inverse agonists from Hello Bio - they are up to half the price of other suppliers.
Ivermectin (IVM) (HB1958)
Description:α7 nicotinic acetylcholine receptor positive allosteric modulator. Activates GluCI/GlyCI chemogenetic channels. Shows antiviral activity.
Purity:>95%
IWP 2 (HB0344)
Description:Potent Wnt pathway inhibitor and PORCN inhibitor. Suppresses R1 ESC self-renewal. Used in the production of cardiac organoids.
Purity:>98%
IWP 4 (HB3066)
Description:Potent Wnt/β-catenin signaling inhibitor. Induces cardiomyocyte differentiation of hESCs and iPSCs.
Purity:>98%
Janelia Fluor® 525, free acid (HB7173)
Description:Yellow dye supplied as a free acid. Suitable for super resolution microscopy (e.g. dSTORM), confocal microscopy and live cell imaging.
Janelia Fluor® 525, SE (HB8455)
Description:Yellow dye for coupling to NHS groups. Suitable for super resolution microscopy (e.g. dSTORM), confocal microscopy and live cell imaging.
Janelia Fluor® 549, Azide (HB7988)
Description:Yellow dye supplied as an azide for click chemistry. Suitable for dSTORM, STED, confocal microscopy, live cell imaging and flow cytometry.
Janelia Fluor® 549, Tetrazine (HB7228)
Description:Yellow dye supplied with a tetrazine reactive handle for copper-free click chemistry. Suitable for dSTORM, STED, confocal microscopy and live cell imaging.
Jasplakinolide (HB3946)
Description:Cell permeable, non-fluorescent F-actin probe. Induces actin polymerization and stabilization.
Purity:>98%