DREADD
Designer receptors exclusively activated by designer drugs (DREADDs) are genetically engineered GPCRs that are activated by physiologically inert synthetic small molecules (designer drugs) but not their endogenous ligand. Read our DREADDs mini-review or for practical advice on using these ligands in the lab see Stability of Water-Soluble DREADD Ligands in Solution: A Technical Review and Clozapine N-Oxide (freebase) - a technical review on stability, solubility and use in the lab).
Nebularine (HB3992)
Description:Naturally occuring nucleoside. DNA, RNA and protein synthesis inhibitor.
Purity:>98%
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Necrostatin-5 (HB3994)
Description:Necroptosis inhibitor. Indirect RIP1 kinase inhibitor.
Purity:>98%
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Necrostatin-7 (HB3995)
Description:Necroptosis inhibitor. Shows no action at RIP1 kinase.
Purity:>98%
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22-NHC (inactive isomer) (HB3719)
Description:Inactive control compound for hedgehog signaling inhibitor 22-NHC
Purity:>98%
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Niclosamide (HB1435)
Description:STAT3 signaling pathway inhibitor. Antineoplastic against AML stem cells.
Purity:>98%
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