Product overview

Name NF 449
Purity >95%
Description Potent, selective, competitive P2X receptor antagonist
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Biological Data

Biological description Potent, selective and competitive P2X receptor antagonist. Selective for P2X1 receptors (IC50 values are 0.3 and 0.7 nM, 0.3, 1.8, 47 and >300 µM for P2X1, P2X1 + 5, P2X2 + 3, P2X3, P2X2 and P2X4 receptors respectively). Also inhibits FGFR3. Shows potential anti-cancer and anti-thrombotic actions.

Solubility & Handling

Solubility overview Soluble in water
Storage instructions Room temperature
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Purity >95%
Chemical name 4,4',4'',4'''-[Carbonylbis(imino-5,1,3-be nzenetriyl-bis(carbonylimino))]tetrakis-1,3-benzen edisulfonic acid, octasodium salt
Molecular Weight 1505.06
Molecular Formula C41H24N6Na8O29S8
CAS Number 627034-85-9
PubChem identifier 91895233
SMILES [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[O-]S(=O)(=O)C1=CC=C(NC(=O)C2=CC(=CC(NC(=O)NC3=CC(=CC(=C3)C(=O)NC3=CC=C(C=C3S([O-])(=O)=O)S([O-])(=O)=O)C(=O)NC3=CC=C(C=C3S([O-])(=O)=O)S([O-])(=O)=O)=C2)C(=O)NC2=CC=C(C=C2S([O-])(=O)=O)S([O-])(=O)=O)C(=C1)S([O-])(=O)=O
InChiKey PHCBPKWKKHYRSA-UHFFFAOYSA-F