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Niclosamide

(HB1435)
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Product overview

Name Niclosamide
Purity >98%
Description STAT3 signaling pathway inhibitor. Antineoplastic against AML stem cells.
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (2) Reviews References (4) Frequently bought together
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Biological Data

Biological description

STAT3 signaling pathway inhibitor which inhibits the activation and transcriptional function of STAT3 and induces cell growth inhibition, apoptosis, and cell cycle arrest of cancer cells with constitutively active STAT3. Shows selectivity for STAT3 over STAT1, STAT5, JAK1, JAK2 and Src kinases.

Also inhibits mTORC and Wnt/β-catenin pathways. Antineoplastic against AML stem cells.

Shows antiproliferative, anticancer, antidiabetic actions. Shows antiparasitic actions and recently investigated as part of COVID-19 compound repurposing.

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in DMSO (10mM), and in ethanol (10mM, gentle warming)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name 5-Chloro-N-(2-chloro-4-nitrophenyl) -2-hydroxybenzamide
Molecular Weight 325.99
Chemical structure Niclosamide | [50-65-7] Chemical Structure
Molecular Formula C13H8Cl2N2O4
CAS Number 50-65-7
PubChem identifier 4477
SMILES C1=CC(=C(C=C1[N+](=O)[O-])Cl)NC(=O)C2=C(C=CC(=C2)Cl)O
InChi InChI=1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19)
InChiKey RJMUSRYZPJIFPJ-UHFFFAOYSA-N
MDL number MFCD00057597
Appearance White solid

References for Niclosamide

References are publications that support the biological activity of the product

  • Inhibition of severe acute respiratory syndrome coronavirus replication by niclosamide

    Hsu et al (2639-6) Antimicrob Agents Chemother. : 48(7)
    Species: 15215127 Read more (PubMedID: 2004)

  • Niclosamide ethanolamine-induced mild mitochondrial uncoupling improves diabetic symptoms in mice.

    Tao H et al (2014) Nat Med 20(11) : 1263-9.
    Read more (PubMedID: 25282357)

  • Identification of Niclosamide as a New Small-Molecule Inhibitor of the STAT3 Signaling Pathway.

    Ren X et al (2010) ACS Med Chem Lett 1(9) : 454-9.
    Read more (PubMedID: 24900231)

  • Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling.

    Balgi AD et al (2009) PLoS One 4(9) : e7124.
    Read more (PubMedID: 19771169)

4 Item(s)

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Order: HB1435
Pack PriceQty
50mg
$143
STAT3 signaling pathway inhibitor. Antineoplastic against AML stem cells.
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

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