STAT3 signaling pathway inhibitor which inhibits the activation and transcriptional function of STAT3 and induces cell growth inhibition, apoptosis, and cell cycle arrest of cancer cells with constitutively active STAT3. Shows selectivity for STAT3 over STAT1, STAT5, JAK1, JAK2 and Src kinases.
Also inhibits mTORC and Wnt/β-catenin pathways. Antineoplastic against AML stem cells.
Shows antiproliferative, anticancer, antidiabetic actions. Shows antiparasitic actions and recently investigated as part of COVID-19 compound repurposing.
Solubility & Handling
Solubility overview
Soluble in DMSO (10mM), and in ethanol (10mM, gentle warming)
Storage instructions
+4°C
Storage of solutions
Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions
Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Y-27632 is a selective ROCK inhibitor. Frequently used 3D growth matrix component and for production of organoids. Also used when inducing neurons from fibroblasts. Manufactured to a high degree of optical purity.
![Niclosamide | [50-65-7] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb1435.png "Niclosamide | [50-65-7]")
Understanding purity and quality - a guide for life scientists
