STAT3 signaling pathway inhibitor which inhibits the activation and transcriptional function of STAT3 and induces cell growth inhibition, apoptosis, and cell cycle arrest of cancer cells with constitutively active STAT3. Shows selectivity for STAT3 over STAT1, STAT5, JAK1, JAK2 and Src kinases.
Also inhibits mTORC and Wnt/β-catenin pathways. Antineoplastic against AML stem cells.
Shows antiproliferative, anticancer, antidiabetic actions. Shows antiparasitic actions and recently investigated as part of COVID-19 compound repurposing.
Solubility & Handling
Soluble in DMSO (10mM), and in ethanol (10mM, gentle warming)
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.