Product overview
| Name | Niclosamide |
| Purity | >98% |
| Description | STAT3 signaling pathway inhibitor. Antineoplastic against AML stem cells. |
Write Your Own Review
Biological Data
| Biological description | STAT3 signaling pathway inhibitor which inhibits the activation and transcriptional function of STAT3 and induces cell growth inhibition, apoptosis, and cell cycle arrest of cancer cells with constitutively active STAT3. Shows selectivity for STAT3 over STAT1, STAT5, JAK1, JAK2 and Src kinases. Also inhibits mTORC and Wnt/β-catenin pathways. Antineoplastic against AML stem cells. Shows antiproliferative, anticancer, antidiabetic actions. Shows antiparasitic actions and recently investigated as part of COVID-19 compound repurposing. |
Solubility & Handling
| Storage instructions | +4°C |
| Solubility overview | Soluble in DMSO (10mM), and in ethanol (10mM, gentle warming) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Purity | >98% |
| Chemical name | 5-Chloro-N-(2-chloro-4-nitrophenyl) -2-hydroxybenzamide |
| Molecular Weight | 325.99 |
| Chemical structure | ![Niclosamide | [50-65-7] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb1435.png "Niclosamide | [50-65-7]") |
| Molecular Formula | C13H8Cl2N2O4 |
| CAS Number | 50-65-7 |
| PubChem identifier | 4477 |
| SMILES | C1=CC(=C(C=C1[N+](=O)[O-])Cl)NC(=O)C2=C(C=CC(=C2)Cl)O |
| InChi | InChI=1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19) |
| InChiKey | RJMUSRYZPJIFPJ-UHFFFAOYSA-N |
| MDL number | MFCD00057597 |
| Appearance | White solid |
Technical guides
Understanding purity and quality - a guide for life scientistsReferences for Niclosamide
References are publications that support the biological activity of the product
-
Inhibition of severe acute respiratory syndrome coronavirus replication by niclosamide
Hsu et al (2639-6) Antimicrob Agents Chemother. : 48(7)Species: 15215127 Read more (PubMedID: 2004) -
Niclosamide ethanolamine-induced mild mitochondrial uncoupling improves diabetic symptoms in mice.
Tao H et al (2014) Nat Med 20(11) : 1263-9. -
Identification of Niclosamide as a New Small-Molecule Inhibitor of the STAT3 Signaling Pathway.
Ren X et al (2010) ACS Med Chem Lett 1(9) : 454-9. -
Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling.
Balgi AD et al (2009) PLoS One 4(9) : e7124.
Related Products
Related Products
- Code:
- HB2297
Y-27632 is a selective ROCK inhibitor. Frequently used 3D growth matrix component and for production of organoids. Also used when inducing neurons from fibroblasts. Manufactured to a high degree of optical purity.
- Code:
- HB3555
Potent, selective TGF-βRI ALK5, ALK4, ALK7 inhibitor. Induces sheet formation...