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L-NMMA

(HB1353)
Publications (1)
Technical documents: SDS CoA Datasheet
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Product overview

Name L-NMMA
Purity >95% (NMR)
Description Competitive, selective NOS inhibitor
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews Publications (1) References (4) Frequently bought together
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L-NMMA product vial image | Hello Bio
L-NMMA product vial image | Hello Bio

L-NMMA product vial image | Hello Bio

L-NMMA product vial image | Hello Bio

Biological Data

Biological description Competitive and selective nitric oxide synthase (NOS) inhibitor (IC50 values are 6.6, 4.9 and 3.5 μM for iNOS, nNOS and eNOS respectively). Also inhibits cyclic GMP (IC50 = 2.9 μM). Displays hypertensive properties.

Solubility & Handling

Solubility overview Soluble in water (50 mM)
Storage instructions Room temperature
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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More Info

Dilution

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Chemical Data

Purity >95% (NMR)
Chemical name N(omega)-Monomethyl-L-Arginine Acetate
Molecular Weight 248.28
Chemical structure L-NMMA [53308-83-1] Chemical Structure
Molecular Formula C7H16N4O2.CH3CO2H
CAS Number 53308-83-1
PubChem identifier 135242
SMILES CC(=O)O.CN=C(N)NCCC[C@@H](C(=O)O)N
InChi InChI=1S/C7H16N4O2.C2H4O2/c1-10-7(9)11-4-2-3-5(8)6(12)13;1-2(3)4/h5H,2-4,8H2,1H3,(H,12,13)(H3,9,10,11);1H3,(H,3,4)/t5-;/m0./s1
InChiKey IKPNWIGTWUZCKM-JEDNCBNOSA-N
MDL number MFCD00069311
Appearance White solid

References for L-NMMA

References are publications that support the biological activity of the product

  • Evidence for the pathophysiological role of endogenous methylarginines in regulation of endothelial NO production and vascular function.

    Cardounel AJ et al (2007) J Biol Chem 282(2) : 879-87.
    Read more (PubMedID: 17082183)

  • Nitric oxide synthases: structure, function and inhibition.

    Alderton WK et al (2001) Biochem J 357(Pt 3) : 593-615.
    Read more (PubMedID: 11463332)

  • L-NMMA (a nitric oxide synthase inhibitor) is effective in the treatment of cardiogenic shock.

    Cotter G et al (2000) Circulation 101(12) : 1358-61.
    Read more (PubMedID: 10736276)

  • Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo.

    Rees DD et al (1990) Br J Pharmacol 101(3) : 746-52.
    Read more (PubMedID: 1706208)

4 Item(s)

Publications
Submit Yours Now
These publications cite the use of L-NMMA purchased from Hello Bio:

  • Soluble guanylate cyclase signalling mediates etoposide resistance in progressing small cell lung cancer

    Schenk MW et al (2021) Nat Commun 12(1) : 6652
    PubMedID: 34789728

1 Item

Related Products
Grouped product items
Order: HB1353
Pack PriceQty
5mg
$30
25mg
$115
50mg
$199
Competitive, selective NOS inhibitor
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

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