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Images
L-NMMA product vial image | Hello Bio
L-NMMA product vial image | Hello Bio
Biological Data
| Biological description | Competitive and selective nitric oxide synthase (NOS) inhibitor (IC50 values are 6.6, 4.9 and 3.5 μM for iNOS, nNOS and eNOS respectively). Also inhibits cyclic GMP (IC50 = 2.9 μM). Displays hypertensive properties. |
Solubility & Handling
| Storage instructions | Room temperature |
| Solubility overview | Soluble in water (50 mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | N(omega)-Monomethyl-L-Arginine Acetate |
| Chemical structure | ![L-NMMA [53308-83-1] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "L-NMMA [53308-83-1]") |
| Molecular Formula | C7H16N4O2.CH3CO2H |
| PubChem identifier | 135242 |
| SMILES | CC(=O)O.CN=C(N)NCCC[C@@H](C(=O)O)N |
| InChi | InChI=1S/C7H16N4O2.C2H4O2/c1-10-7(9)11-4-2-3-5(8)6(12)13;1-2(3)4/h5H,2-4,8H2,1H3,(H,12,13)(H3,9,10,11);1H3,(H,3,4)/t5-;/m0./s1 |
| InChiKey | IKPNWIGTWUZCKM-JEDNCBNOSA-N |
References for L-NMMA
References are publications that support the biological activity of the product
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Evidence for the pathophysiological role of endogenous methylarginines in regulation of endothelial NO production and vascular function.
Cardounel AJ et al (2007) J Biol Chem 282(2) : 879-87. -
Nitric oxide synthases: structure, function and inhibition.
Alderton WK et al (2001) Biochem J 357(Pt 3) : 593-615. -
L-NMMA (a nitric oxide synthase inhibitor) is effective in the treatment of cardiogenic shock.
Cotter G et al (2000) Circulation 101(12) : 1358-61. -
Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo.
Rees DD et al (1990) Br J Pharmacol 101(3) : 746-52.
Publications
These publications cite the use of L-NMMA purchased from Hello Bio:
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Soluble guanylate cyclase signalling mediates etoposide resistance in progressing small cell lung cancer
Schenk MW et al (2021) Nat Commun 12(1) : 6652
Competitive, selective NOS inhibitor
![L-NMMA [53308-83-1] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb1353.png "L-NMMA [53308-83-1]")
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