Histone deacetylase (HDAC)

Histone acetylation is a key epigenetic process - it is upregulated during memory formation but downregulated in numerous neurodegenerative diseases (eg. Alzheimer's disease and Huntington's disease). There are 18 Histone Deacetylase (HDAC) enzymes that are classified into two groups, the histone deacetylase family and the sirtuin family. The histone deacetylase family is further divided into classes I, II and IV. HDAC inhibitors are a class of compounds that increase acetylation of lysine residues on histone proteins as well as other, nonhistone, proteins by inhibiting the activity of these HDAC enzymes. Researchers can save up to 50% on HDAC inhibitors from Hello Bio - they are up to half the price of other suppliers.

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  1. Carboplatin (HB3824)

    Description:

    Cisplatin analog. Blocks DNA replication and transcription.

    Purity:

    >98%

    Pack:
    250mg
    Price:
    $313
    Qty:
  2. Pack:
    500mg
    Price:
    $98
    Qty:
  3. CCG 1423 (HB3389)

    Description:

    Rho/SRF pathway inhibitor. Induces intermediate mesoderm differentiation from ESCs.

    Purity:

    >99%

    Pack:
    10mg
    Price:
    $117
    Qty:
    Pack:
    50mg
    Price:
    $433
    Qty:
  4. Cephalochromin (HB3825)

    Description:

    Selective Fabl inhibitor. Apoptosis inducer.

    Purity:

    >98%

    Pack:
    5mg
    Price:
    $542
    Qty:
  5. cGAMP disodium (HB3827)

    Description:

    Potent STING ligand

    Purity:

    >98%

    Pack:
    500μg
    Price:
    $329
    Qty:
  6. Description:

    Antibiotic with antibacterial, antifungal and cytotoxic activity. Selectively induces apoptosis of CLL cells.

    Purity:

    >98%

    Pack:
    5mg
    Price:
    $453
    Qty:
  7. Chalcomycin (HB3830)

    Description:

    Macrolide antibiotic with antimicrobial and antibacterial activity

    Purity:

    >96%

    Pack:
    1mg
    Price:
    $208
    Qty:
  8. Pack:
    5g
    Price:
    $112
    Qty:
  9. CHIR 99021 (HB1261)

    Description:

    Potent, selective GSK3 inhibitor and Wnt signaling activator. Commonly used in organoid production and involved in reprogramming MEFs to IPSCs and fibroblasts to mature neurons.

    Purity:

    >98%

    Pack:
    1mg
    Price:
    $50
    Qty:
    Pack:
    2mg
    Price:
    Qty:
    Pack:
    5×2mg
    Price:
    $188
    Qty:
    Pack:
    10mg
    Price:
    $182
    Qty:
    Pack:
    5mg
    Price:
    $117
    Qty:
    Pack:
    25mg
    Price:
    $445
    Qty:
    Pack:
    50mg
    Price:
    $758
    Qty:
    Pack:
    10mM (1mL in DMSO)
    Price:
    $126
    Qty:
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