CCCP is a protonophore which is a widely used uncoupler of mitochondrial oxidative phosphorylation.
CCCP disrupts ATP synthesis by transporting protons across the mitochondrial inner membrane, interfering with the proton gradient.
By depolarizing the plasma membrane and reducing ATP production, CCCP can indirectly affect proton pump activity and cellular metabolism to cause cell death.
Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions
Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use
References are publications that support the biological activity of the product
Carbonyl Cyanide m-Chlorophenylhydrazine (CCCP) Reverses Resistance to Colistin, but Not to Carbapenems and Tigecycline in Multidrug-Resistant Enterobacteriaceae.
Carbonyl cyanide p-(trifluoromethoxy) phenylhydrazone (FCCP) as an O2(*-) generator induces apoptosis via the depletion of intracellular GSH contents in Calu-6 cells.
![CCCP [555-60-2 ] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb5062_1.png "CCCP [555-60-2 ]")
