Product overview

Alternative names Carbonyl cyanide m-chlorophenylhydrazone
Purity >98%
Description Potent uncoupler of mitochondrial oxidative phosphorylation
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Biological Data

Biological description

CCCP is a protonophore which is a widely used uncoupler of mitochondrial oxidative phosphorylation.

CCCP disrupts ATP synthesis by transporting protons across the mitochondrial inner membrane, interfering with the proton gradient.

By depolarizing the plasma membrane and reducing ATP production, CCCP can indirectly affect proton pump activity and cellular metabolism to cause cell death.

The uncoupling agent FCCP is also available.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in DMSO (100 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use



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Chemical Data

Purity >98%
Chemical name Carbonyl cyanide 3-chlorophenylhydrazone
Molecular Weight 204.62
Chemical structure CCCP [555-60-2 ] Chemical Structure
Molecular Formula C9H5ClN4
CAS Number 555-60-2
PubChem identifier 2603
Source Synthetic
InChi InChI=1S/C9H5ClN4/c10-7-2-1-3-8(4-7)13-14-9(5-11)6-12/h1-4,13H
MDL number MFCD00001848
Appearance Yellow solid

References for CCCP

References are publications that support the biological activity of the product
  • Carbonyl Cyanide m-Chlorophenylhydrazine (CCCP) Reverses Resistance to Colistin, but Not to Carbapenems and Tigecycline in Multidrug-Resistant Enterobacteriaceae.

    Sekyere and Amoako (2017) Front Microbiol 8 : 228
  • Carbonyl cyanide p-(trifluoromethoxy) phenylhydrazone (FCCP) as an O2(*-) generator induces apoptosis via the depletion of intracellular GSH contents in Calu-6 cells.

    Han et al (2009) Lung Cancer 63(2) : 201-9
  • Mitochondrial uncouplers with an extraordinary dynamic range.

    Lou et al (2007) Biochem J 407(1) : 129-40
  • The protonophore CCCP induces mitochondrial permeability transition without cytochrome c release in human osteosarcoma cells.

    LIm et al (2001) FEBS Lett 503(1) : 69-74

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