Target

HIV-1 and HIV-2 protease inhibitor

Selective TRPV4 agonist

Selective D₂-like receptor agonist

Potent and selective PPARγ agonist. Promotes adipocyte differentiation and enhances NPC proliferation.

Potent and selective PPARγ agonist; antidiabetic agent.

Dopamine D₂ and D₃ receptor agonist

Cell permeable Sonic hedgehog (Shh) agonist and Smo agonist. Enhances neuronal differentiation of iPSC into dopaminergic neurons.

Highly active Sonic hedgehog agonist. Also smoothened (Smo) agonist.

Low toxicity Sonic hedgehog agonist. Also smoothened (Smo) agonist.

Potent, selective KORD DREADD activator