Product overview
| Name | Salvinorin B (SALB) |
| Description | Potent, selective KORD DREADD activator |
| Alternative names | SALB, Divinorin B |
| Purity | >98% |
| Customer comments | High quality with better price. I have compared SalB (Salvinorin B)) from different producer, Hello Bio really provide a high quality compound with a cheaper price. Would definitely order again from here. Verified customer, Stony Brook University |
Biological Data
| Biological description | Salvinorin B (SALB) is a pharmacologically inert ligand that potently and selectively activates the KORD (the κ-opioid designer receptor (DREADD)) (EC50 = 11.8 nM).
|
Solubility & Handling
| Storage instructions | -20°C |
| Solubility overview | Soluble in DMSO (20 mM) |
| Handling |
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| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | (2S,4aR,6aR,7R,9S,10aS,10bR)-2-(3-Furanyl)dodecahydro-9-hydroxy-6a,10b-dimethyl-4,10-dioxo-2H-naphtho[2,1-c]pyran-7-carboxylic acid methyl ester |
| Molecular Weight | 390.43 |
| Chemical structure | ![Salvinorin B | [92545-30-7] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb4887.png "Salvinorin B | [92545-30-7]") |
| Molecular Formula | C21H26O7 |
| CAS Number | 92545-30-7 |
| PubChem identifier | 11440685 |
| SMILES | C[C@@]12CC[C@H]3C(=O)O[C@@H](C[C@@]3([C@H]1C(=O)[C@H](C[C@H]2C(=O)OC)O)C)C4=COC=C4 |
| Source | Extracted from salvia divinorum |
| InChi | InChI=1S/C21H26O7/c1-20-6-4-12-19(25)28-15(11-5-7-27-10-11)9-21(12,2)17(20)16(23)14(22)8-13(20)18(24)26-3/h5,7,10,12-15,17,22H,4,6,8-9H2,1-3H3/t12-,13-,14-,15-,17-,20-,21-/m0/s1 |
| InChiKey | BLTMVAIOAAGYAR-CEFSSPBYSA-N |
| MDL number | MFCD16036232 |
| Appearance | Off-white solid |
References for Salvinorin B (SALB)
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DREADDS: Use and application in behavioral neuroscience.
Smith et al (206) Behav Neurosci 130(2) : 137-55. -
DREADDs: The Power of the Lock, the Weakness of the Key. Favoring the Pursuit of Specific Conditions Rather than Specific Ligands.
Goutaudier et al (2019) eNeuro 6 : (5) -
Behavioral and Physiological Effects of a Novel Kappa-Opioid Receptor-Based DREADD in Rats.
Marchant et al (2016) Neuropsychopharmacology 41(2) : 402-9. -
A New DREADD Facilitates the Multiplexed Chemogenetic Interrogation of Behavior.
Vardy et al (2015) Neuron. 86(4) : 936-46. -
Antinociceptive and hypothermic effects of Salvinorin A are abolished in a novel strain of kappa-opioid receptor-1 knockout mice.
Ansonoff MA et al (2006) J Pharmacol Exp Ther 318 (2): : 641-8.
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Microglia modulate stable wakefulness via the thalamic reticular nucleus in mice
Liu et al (2021) Nat Commun. : 12(1)PubMedID: 34330901 -
mGlu2 and mGlu3 Negative Allosteric Modulators Divergently Enhance Thalamocortical Transmission and Exert Rapid Antidepressant-like Effects
Joffe et al. (2020) Neuron 105(1) : 46-59PubMedID: 31735403
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