Salvinorin B (SALB)
(HB4887) Product overview
Description Potent, selective KORD DREADD activator
Alternative names SALB, Divinorin B
High quality with better price. I have compared SalB (Salvinorin B)) from different producer, Hello Bio really provide a high quality compound with a cheaper price. Would definitely order again from here. Verified customer, Stony Brook University Biological Data
Salvinorin B (SALB) is a pharmacologically inert ligand that potently and selectively activates the KORD (the κ-opioid designer receptor (DREADD)) (EC
50 = 11.8 nM).
Salvinorin B (SALB) is ~100-fold selective for the KORD DREADD over human κ opioid receptor and other targets and shows good CNS penetrability.
Activation of KORD by Salvinorin B (SALB) induces neuronal inhibition and modifies behaviour in vivo.
Salvinorin B (SALB) can be used in mice also expressing Clozapine N-Oxide (CNO) responsive DREADDS, to allow bi-directional manipulation of neural circuits.
CNO dihydrochloride (water soluble), Clozapine N-oxide (CNO) freebase, Compound 21 and perlapine freebase also available. Solubility & Handling
Storage instructions -20°C
Solubility overview Soluble in DMSO (20 mM)
This compound is light sensitive; we therefore recommend protecting the solid and solutions from exposure to light.
Salvinorin B (SalB) is unstable in solution and we recommend that solutions are stored at -20°C and used within 24 hours.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. Chemical Data
Chemical name (2S,4aR,6aR,7R,9S,10aS,10bR)-2-(3-Furanyl)dodecahydro-9-hydroxy-6a,10b-dimethyl-4,10-dioxo-2H-naphtho[2,1-c]pyran-7-carboxylic acid methyl ester
Molecular Formula C 21H 26O 7
PubChem identifier 11440685
Source Extracted from salvia divinorum
Appearance Off-white solid References for Salvinorin B (SALB)
References are publications that support the biological activity of the product
DREADDS: Use and application in behavioral neuroscience. Smith et al (206) Behav Neurosci 130(2) : 137-55. DREADDs: The Power of the Lock, the Weakness of the Key. Favoring the Pursuit of Specific Conditions Rather than Specific Ligands. Goutaudier et al (2019) eNeuro 6 : (5) Behavioral and Physiological Effects of a Novel Kappa-Opioid Receptor-Based DREADD in Rats. Marchant et al (2016) Neuropsychopharmacology 41(2) : 402-9. A New DREADD Facilitates the Multiplexed Chemogenetic Interrogation of Behavior. Vardy et al (2015) Neuron. 86(4) : 936-46. Antinociceptive and hypothermic effects of Salvinorin A are abolished in a novel strain of kappa-opioid receptor-1 knockout mice. Ansonoff MA et al (2006) J Pharmacol Exp Ther 318 (2): : 641-8.
These publications cite the use of Salvinorin B (SALB) purchased from Hello Bio:
Microglia modulate stable wakefulness via the thalamic reticular nucleus in mice Liu et al (2021) Nat Commun. : 12(1) mGlu2 and mGlu3 Negative Allosteric Modulators Divergently Enhance Thalamocortical Transmission and Exert Rapid Antidepressant-like Effects Joffe et al. (2020) Neuron 105(1) : 46-59