3  Reviews
Top Reviews:
100% of 100
Add Your Review

Salvinorin B (SALB)

Technical documents: SDS CoA Datasheet

Product overview

Name Salvinorin B (SALB)
Alternative names SALB, Divinorin B
Purity >98%
Customer comments

High quality with better price. I have compared SalB (Salvinorin B)) from different producer, Hello Bio really provide a high quality compound with a cheaper price. Would definitely order again from here. Verified customer, Stony Brook University

Description Potent, selective KORD DREADD activator
Write Your Own Review
You're reviewing:Salvinorin B (SALB)
Rate this item:

Biological Data

Biological description

Salvinorin B (SALB) is a pharmacologically inert ligand that potently and selectively activates the KORD (the κ-opioid designer receptor (DREADD)) (EC50 = 11.8 nM).

Salvinorin B (SALB) is ~100-fold selective for the KORD DREADD over human κ opioid receptor and other targets and shows good CNS penetrability.

Activation of KORD by Salvinorin B (SALB) induces neuronal inhibition and modifies behaviour in vivo.

Salvinorin B (SALB) can be used in mice also expressing Clozapine N-Oxide (CNO) responsive DREADDS, to allow bi-directional manipulation of neural circuits.

CNO dihydrochloride (water soluble), Clozapine N-oxide (CNO) freebase, Compound 21 and perlapine freebase also available.

Please note this item is not for sale in Canada

Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in DMSO (20 mM)

  • This compound is light sensitive; we therefore recommend protecting the solid and solutions from exposure to light.
  • Salvinorin B (SalB) is unstable in solution and we recommend that solutions are stored at -20°C and used within 24 hours.

Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



More Info


More Info

Chemical Data

Purity >98%
Chemical name (2S,4aR,6aR,7R,9S,10aS,10bR)-2-(3-Furanyl)dodecahydro-9-hydroxy-6a,10b-dimethyl-4,10-dioxo-2H-naphtho[2,1-c]pyran-7-carboxylic acid methyl ester
Molecular Weight 390.43
Chemical structure Salvinorin B | [92545-30-7] Chemical Structure
Molecular Formula C21H26O7
CAS Number 92545-30-7
PubChem identifier 11440685
SMILES C[C@@]12CC[C@H]3C(=O)O[C@@H](C[C@@]3([C@H]1C(=O)[C@H](C[C@H]2C(=O)OC)O)C)C4=COC=C4
Source Extracted from salvia divinorum
InChi InChI=1S/C21H26O7/c1-20-6-4-12-19(25)28-15(11-5-7-27-10-11)9-21(12,2)17(20)16(23)14(22)8-13(20)18(24)26-3/h5,7,10,12-15,17,22H,4,6,8-9H2,1-3H3/t12-,13-,14-,15-,17-,20-,21-/m0/s1
MDL number MFCD16036232
Appearance Off-white solid

References for Salvinorin B (SALB)

References are publications that support the biological activity of the product
  • DREADDS: Use and application in behavioral neuroscience.

    Smith et al (206) Behav Neurosci 130(2) : 137-55.
  • DREADDs: The Power of the Lock, the Weakness of the Key. Favoring the Pursuit of Specific Conditions Rather than Specific Ligands.

    Goutaudier et al (2019) eNeuro 6 : (5)
  • Behavioral and Physiological Effects of a Novel Kappa-Opioid Receptor-Based DREADD in Rats.

    Marchant et al (2016) Neuropsychopharmacology 41(2) : 402-9.
  • A New DREADD Facilitates the Multiplexed Chemogenetic Interrogation of Behavior.

    Vardy et al (2015) Neuron. 86(4) : 936-46.
  • Antinociceptive and hypothermic effects of Salvinorin A are abolished in a novel strain of kappa-opioid receptor-1 knockout mice.

    Ansonoff MA et al (2006) J Pharmacol Exp Ther 318 (2): : 641-8.

5 Item(s)

These publications cite the use of Salvinorin B (SALB) purchased from Hello Bio:
  • The parasubthalamic nucleus refeeding ensemble delays feeding initiation

    Dunning et al (2023) bioRxiv : https://doi.org/10.1101/2023.01.28.525750
  • Hypothalamic astrocyte control systemic glucose metabolism and energy balance via regulation of extra-synaptic glutamate signaling

    Luquet et al (2022) Biorxiv : https://doi.org/10.1101/2022.02.16.480737
  • Inhibitory Fear Memory Engram in the Mouse Central Lateral Amygdala

    Hou et al et al (2022) Cell Reports 72
  • Microglia modulate stable wakefulness via the thalamic reticular nucleus in mice

    Liu et al (2021) Nat Commun. : 12(1)
    PubMedID: 34330901
  • Somatostatin neurons control an alcohol binge drinking prelimbic microcircuit in mice

    Dao NC et al (2021) Neuropsychopharmacology 46(11) : 1906-1917
    PubMedID: 34112959

Items 1 to 5 of 7 total