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Salvinorin B (SALB)
(HB4887) Product overview
Alternative names SALB, Divinorin B
High quality with better price. I have compared SalB (Salvinorin B)) from different producer, Hello Bio really provide a high quality compound with a cheaper price. Would definitely order again from here. Verified customer, Stony Brook University
Description Potent, selective KORD DREADD activator Biological Data
Salvinorin B (SALB) is a pharmacologically inert ligand that potently and selectively activates the KORD (the κ-opioid designer receptor (DREADD)) (EC
50 = 11.8 nM).
Salvinorin B (SALB) is ~100-fold selective for the KORD DREADD over human κ opioid receptor and other targets and shows good CNS penetrability.
Activation of KORD by Salvinorin B (SALB) induces neuronal inhibition and modifies behaviour in vivo.
Salvinorin B (SALB) can be used in mice also expressing Clozapine N-Oxide (CNO) responsive DREADDS, to allow bi-directional manipulation of neural circuits.
CNO dihydrochloride (water soluble), Clozapine N-oxide (CNO) freebase, Compound 21 and perlapine freebase also available.
Please note this item is not for sale in Canada Solubility & Handling
Storage instructions -20°C
Solubility overview Soluble in DMSO (20 mM)
This compound is light sensitive; we therefore recommend protecting the solid and solutions from exposure to light.
Salvinorin B (SalB) is unstable in solution and we recommend that solutions are stored at -20°C and used within 24 hours.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. Chemical Data
Chemical name (2S,4aR,6aR,7R,9S,10aS,10bR)-2-(3-Furanyl)dodecahydro-9-hydroxy-6a,10b-dimethyl-4,10-dioxo-2H-naphtho[2,1-c]pyran-7-carboxylic acid methyl ester
Molecular Formula C 21H 26O 7
PubChem identifier 11440685
Source Extracted from salvia divinorum
Appearance Off-white solid References for Salvinorin B (SALB)
References are publications that support the biological activity of the product
DREADDS: Use and application in behavioral neuroscience. Smith et al (206) Behav Neurosci 130(2) : 137-55. DREADDs: The Power of the Lock, the Weakness of the Key. Favoring the Pursuit of Specific Conditions Rather than Specific Ligands. Goutaudier et al (2019) eNeuro 6 : (5) Behavioral and Physiological Effects of a Novel Kappa-Opioid Receptor-Based DREADD in Rats. Marchant et al (2016) Neuropsychopharmacology 41(2) : 402-9. A New DREADD Facilitates the Multiplexed Chemogenetic Interrogation of Behavior. Vardy et al (2015) Neuron. 86(4) : 936-46. Antinociceptive and hypothermic effects of Salvinorin A are abolished in a novel strain of kappa-opioid receptor-1 knockout mice. Ansonoff MA et al (2006) J Pharmacol Exp Ther 318 (2): : 641-8.
These publications cite the use of Salvinorin B (SALB) purchased from Hello Bio:
The parasubthalamic nucleus refeeding ensemble delays feeding initiation Dunning et al (2023) bioRxiv : https://doi.org/10.1101/2023.01.28.525750 Hypothalamic astrocyte control systemic glucose metabolism and energy balance via regulation of extra-synaptic glutamate signaling Luquet et al (2022) Biorxiv : https://doi.org/10.1101/2022.02.16.480737 Inhibitory Fear Memory Engram in the Mouse Central Lateral Amygdala Hou et al et al (2022) Cell Reports 72 Microglia modulate stable wakefulness via the thalamic reticular nucleus in mice Liu et al (2021) Nat Commun. : 12(1) Somatostatin neurons control an alcohol binge drinking prelimbic microcircuit in mice Dao NC et al (2021) Neuropsychopharmacology 46(11) : 1906-1917
Potent, selective KORD DREADD activator