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Biological Data Biological description Salvinorin B (SALB) is a pharmacologically inert ligand that potently and selectively activates the KORD (the κ-opioid designer receptor (DREADD)) (EC50 = 11.8 nM).
CNO dihydrochloride (water soluble), Clozapine N-oxide (CNO) freebase, Compound 21 Â and perlapine freebase also available.
Please note this item is not for sale in Canada
Solubility & Handling Solubility overview Soluble in DMSO (20 mM)
Storage instructions -20°C
Handling
This compound is light sensitive; we therefore recommend protecting the solid and solutions from exposure to light.
Salvinorin B (SalB) is unstable in solution and we recommend that solutions are stored at -20°C and used within 24 hours.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical name (2S,4aR,6aR,7R,9S,10aS,10bR)-2-(3-Furanyl)dodecahydro-9-hydroxy-6a,10b-dimethyl-4,10-dioxo-2H-naphtho[2,1-c]pyran-7-carboxylic acid methyl ester
Chemical structure
Molecular Formula C21 H26 O7
PubChem identifier 11440685
SMILES C[C@@]12CC[C@H]3C(=O)O[C@@H](C[C@@]3([C@H]1C(=O)[C@H](C[C@H]2C(=O)OC)O)C)C4=COC=C4
Source Extracted from salvia divinorum
InChi InChI=1S/C21H26O7/c1-20-6-4-12-19(25)28-15(11-5-7-27-10-11)9-21(12,2)17(20)16(23)14(22)8-13(20)18(24)26-3/h5,7,10,12-15,17,22H,4,6,8-9H2,1-3H3/t12-,13-,14-,15-,17-,20-,21-/m0/s1
InChiKey BLTMVAIOAAGYAR-CEFSSPBYSA-N
Appearance Off-white solid
References for Salvinorin B (SALB) References are publications that support the biological activity of the product
DREADDS: Use and application in behavioral neuroscience. Smith et al (206) Behav Neurosci 130(2) : 137-55. DREADDs: The Power of the Lock, the Weakness of the Key. Favoring the Pursuit of Specific Conditions Rather than Specific Ligands. Goutaudier et al (2019) eNeuro 6 : (5) Behavioral and Physiological Effects of a Novel Kappa-Opioid Receptor-Based DREADD in Rats. Marchant et al (2016) Neuropsychopharmacology 41(2) : 402-9. A New DREADD Facilitates the Multiplexed Chemogenetic Interrogation of Behavior. Vardy et al (2015) Neuron. 86(4) : 936-46. Antinociceptive and hypothermic effects of Salvinorin A are abolished in a novel strain of kappa-opioid receptor-1 knockout mice. Ansonoff MA et al (2006) J Pharmacol Exp Ther 318 (2): : 641-8.
Publications
These publications cite the use of Salvinorin B (SALB) purchased from Hello Bio:
The parasubthalamic nucleus refeeding ensemble delays feeding initiation and hastens water drinking. Dunning JL et al (2024) Molecular psychiatry The parasubthalamic nucleus refeeding ensemble delays feeding initiation Dunning et al (2023) bioRxiv : https://doi.org/10.1101/2023.01.28.525750
Hypothalamic astrocyte control systemic glucose metabolism and energy balance via regulation of extra-synaptic glutamate signaling Luquet et al (2022) Biorxiv : https://doi.org/10.1101/2022.02.16.480737
Inhibitory Fear Memory Engram in the Mouse Central Lateral Amygdala Hou et al et al (2022) Cell Reports 72
Microglia modulate stable wakefulness via the thalamic reticular nucleus in mice Liu et al (2021) Nat Commun. : 12(1)
Potent, selective KORD DREADD activator
![Salvinorin B | [92545-30-7] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb4887.png "Salvinorin B | [92545-30-7]")
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