Salvinorin B (SALB)

(HB4887)
Technical documents: SDS CoA Datasheet

Product overview

Name Salvinorin B (SALB)
Description Potent, selective KORD DREADD activator
Alternative names SALB, Divinorin B
Purity >98%
Customer comments

High quality with better price. I have compared SalB (Salvinorin B)) from different producer, Hello Bio really provide a high quality compound with a cheaper price. Would definitely order again from here. Verified customer, Stony Brook University

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Biological Data

Biological description

Salvinorin B (SALB) is a pharmacologically inert ligand that potently and selectively activates the KORD (the κ-opioid designer receptor (DREADD)) (EC50 = 11.8 nM).


Salvinorin B (SALB) is ~100-fold selective for the KORD DREADD over human κ opioid receptor and other targets and shows good CNS penetrability.


Activation of KORD by Salvinorin B (SALB) induces neuronal inhibition and modifies behaviour in vivo.


Salvinorin B (SALB) can be used in mice also expressing Clozapine N-Oxide (CNO) responsive DREADDS, to allow bi-directional manipulation of neural circuits.


CNO dihydrochloride (water soluble), Clozapine N-oxide (CNO) freebase, Compound 21 and perlapine freebase also available.

Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in DMSO (20 mM)
Handling

  • This compound is light sensitive; we therefore recommend protecting the solid and solutions from exposure to light.
  • Salvinorin B (SalB) is unstable in solution and we recommend that solutions are stored at -20°C and used within 24 hours.

Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Chemical name (2S,4aR,6aR,7R,9S,10aS,10bR)-2-(3-Furanyl)dodecahydro-9-hydroxy-6a,10b-dimethyl-4,10-dioxo-2H-naphtho[2,1-c]pyran-7-carboxylic acid methyl ester
Molecular Weight 390.43
Chemical structure Salvinorin B | [92545-30-7] Chemical Structure
Molecular Formula C21H26O7
CAS Number 92545-30-7
PubChem identifier 11440685
SMILES C[C@@]12CC[C@H]3C(=O)O[C@@H](C[C@@]3([C@H]1C(=O)[C@H](C[C@H]2C(=O)OC)O)C)C4=COC=C4
Source Extracted from salvia divinorum
InChi InChI=1S/C21H26O7/c1-20-6-4-12-19(25)28-15(11-5-7-27-10-11)9-21(12,2)17(20)16(23)14(22)8-13(20)18(24)26-3/h5,7,10,12-15,17,22H,4,6,8-9H2,1-3H3/t12-,13-,14-,15-,17-,20-,21-/m0/s1
InChiKey BLTMVAIOAAGYAR-CEFSSPBYSA-N
MDL number MFCD16036232
Appearance Off-white solid

References for Salvinorin B (SALB)

References are publications that support the biological activity of the product
  • DREADDS: Use and application in behavioral neuroscience.

    Smith et al (206) Behav Neurosci 130(2) : 137-55.
  • DREADDs: The Power of the Lock, the Weakness of the Key. Favoring the Pursuit of Specific Conditions Rather than Specific Ligands.

    Goutaudier et al (2019) eNeuro 6 : (5)
  • Behavioral and Physiological Effects of a Novel Kappa-Opioid Receptor-Based DREADD in Rats.

    Marchant et al (2016) Neuropsychopharmacology 41(2) : 402-9.
  • A New DREADD Facilitates the Multiplexed Chemogenetic Interrogation of Behavior.

    Vardy et al (2015) Neuron. 86(4) : 936-46.
  • Antinociceptive and hypothermic effects of Salvinorin A are abolished in a novel strain of kappa-opioid receptor-1 knockout mice.

    Ansonoff MA et al (2006) J Pharmacol Exp Ther 318 (2): : 641-8.
Publications
These publications cite the use of Salvinorin B (SALB) purchased from Hello Bio:
  • Microglia modulate stable wakefulness via the thalamic reticular nucleus in mice

    Liu et al (2021) Nat Commun. : 12(1)
    PubMedID: 34330901
  • mGlu2 and mGlu3 Negative Allosteric Modulators Divergently Enhance Thalamocortical Transmission and Exert Rapid Antidepressant-like Effects

    Joffe et al. (2020) Neuron 105(1) : 46-59
    PubMedID: 31735403

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