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Ritonavir

(HB6070)
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Product overview

Name Ritonavir
Alternative names ABT-538 , A-84538 , Abbot 84538
Purity >98%
Description HIV-1 and HIV-2 protease inhibitor
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (3)
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Biological Data

Biological description

HIV-1 and HIV-2 protease inhibitor, frequently used in immunometabolism research.

Potentially binds and inhibits the CEP_C30 (coronavirus endopeptidase C30) of SARS-CoV-2 and when used with lopinavir has shown to improve animal models of MERS-CoV.

Also shows antitumour activity and induces apoptosis.

Solubility & Handling

Solubility overview Soluble in DMSO (20mM, gentle warming) and ethanol (10mM)
Storage instructions -20°C
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name 5-Thiazolylmethyl (3S,4S,6S,9S)-4-hydroxy-12-methyl-9- (1-methylethyl)-13-[2- (1-methylethyl)-4-thiazolyl]-8,11-dioxo-3,6-bis (phenylmethyl)-2,7,10,12-tetraazatridecanoate
Molecular Weight 720.94
Chemical structure Ritovavir [155213-67-5] Chemical Structure
Molecular Formula C37H48N6O5S2
CAS Number 155213-67-5
PubChem identifier 392622
SMILES O[C@@H] (C[C@@H] (NC ([C@H] (C (C)C)NC (N (C)CC1=CSC (C (C)C)=N1)=O)=O)CC2=CC=CC=C2)[C@@H] (NC (OCC3=CN=CS3)=O)CC4=CC=CC=C4
InChi InChI=1S/C37H48N6O5S2/c1-24(2)33(42-36(46)43(5)20-29-22-49-35(40-29)25(3)4)34(45)39-28(16-26-12-8-6-9-13-26)18-32(44)31(17-27-14-10-7-11-15-27)41-37(47)48-21-30-19-38-23-50-30/h6-15,19,22-25,28,31-33,44H,16-18,20-21H2,1-5H3,(H,39,45)(H,41,47)(H,42,46)/t28
InChiKey NCDNCNXCDXHOMX-XGKFQTDJSA-N
MDL number MFCD00927142

References for Ritonavir

References are publications that support the biological activity of the product

  • Predicting commercially available antiviral drugs that may act on the novel coronavirus (SARS-CoV-2) through a drug-target interaction deep learning model

    Beck BR et al (2020) Comput Struct Biotechnol J 18 : 784-790
    Read more (PubMedID: 32280433)

  • Treatment With Lopinavir/Ritonavir or Interferon-β1b Improves Outcome of MERS-CoV Infection in a Nonhuman Primate Model of Common Marmoset

    Chan JF et al (2015) J Infect Dis 212(12) : 1904-13
    Read more (PubMedID: 26198719)

  • Pharmacological and therapeutic properties of ritonavir-boosted protease inhibitor therapy in HIV-infected patients

    Zeldin RK et al (2004) J Antimicrob Chemother 53(1) : 44078
    Read more (PubMedID: 14657084)

3 Item(s)

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Grouped product items
Order: HB6070
Pack PriceQty
10mg
$36
50mg
$108
HIV-1 and HIV-2 protease inhibitor
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

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Fax 609-228-4994

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Potent and selective HIV-1 protease inhibitor