Hedgehog signaling

Potent, selective CaM antagonist

Epithelial K_Ca channel activator. Promotes ESC differentiation into cardiomyocytes.

Broad enzyme inhibitor. Inhibits Gq protein signaling.

Synthetic retinoid. Induces neural differentiation of hESCs.

G(2)/M phase cell cycle inhibitor

Ion chelator

Calcium specific chelator

Potent adenosine deaminase and PDE2 inhibitor. Supresses spontaneous hESC differentiation. Also maintains pluripotency of hESCs in the absence of exogenous cytokines.

Leukocyte elastase inhibitor

Non-competitive, GluN2B subunit selective NMDA receptor antagonist