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Eliprodil

(HB0274)
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Product overview

Name Eliprodil
Purity >98%
Description Non-competitive, GluN2B subunit selective NMDA receptor antagonist
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (4) Reviews References (4) Frequently bought together
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Biological Data

Biological description Non-competitive and GluN2B subunit selective NMDA receptor antagonist. Binds at the polyamine site. IC50 values are 1, >100 and >100 µM for GluN2B, GluN2A and GluN2C respectively. Also Inhibits voltage- dependent Ca2+ channels. Shows neuroprotective actions and potentiates anticonvulsant effects of CGP 37849.

Solubility & Handling

Solubility overview Soluble in DMSO (25mM)
Storage instructions +4°C (desiccate)
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name α-(4-Chlorophenyl)-4-[(4-fluorophenyl)methyl]-1-piperidineethanol
Molecular Weight 347.86
Chemical structure Eliprodil [119431-25-3] Chemical Structure
Molecular Formula C20H23ClFNO
CAS Number 119431-25-3
PubChem identifier 60703
SMILES C1CN(CCC1CC2=CC=C(C=C2)F)CC(C3=CC=C(C=C3)Cl)O
InChi InChI=1S/C20H23ClFNO/c21-18-5-3-17(4-6-18)20(24)14-23-11-9-16(10-12-23)13-15-1-7-19(22)8-2-15/h1-8,16,20,24H,9-14H2
InChiKey GGUSQTSTQSHJAH-UHFFFAOYSA-N
MDL number MFCD00866651

References for Eliprodil

References are publications that support the biological activity of the product

  • Antagonism of NMDA receptors by sigma site ligands: potency, subtype-selectivity and mechanisms of inhibition.

    Whittemore ER et al (1997) J Pharmacol Exp Ther 282(1) : 326-38.
    Read more (PubMedID: 9223571)

  • The effects of ifenprodil and eliprodil on voltage-dependent Ca2+ channels and in gerbil global cerebral ischaemia.

    Bath CP et al (1996) Eur J Pharmacol 299(1-3) : 103-12.
    Read more (PubMedID: 8901012)

  • Prevention by eliprodil (SL 82.0715) of traumatic brain damage in the rat. Existence of a large (18 h) therapeutic window.

    Toulmond S et al (1993) Prevention by eliprodil (SL 82 620(1) : 32-41.
    Read more (PubMedID: 8402196)

  • Central effects of SL 82.0715, an antagonist of polyamine site of the NMDA receptor complex.

    Dereń-Wesołek A et al (1993) Central effects of SL 82 45(5-6) : 467-80.
    Read more (PubMedID: 7912135)

4 Item(s)

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Order: HB0274
Pack PriceQty
10mg
$101
Non-competitive, GluN2B subunit selective NMDA receptor antagonist
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