Non-competitive and GluN2B subunit selective NMDA receptor antagonist. Binds at the polyamine site. IC50 values are 1, >100 and >100 µM for GluN2B, GluN2A and GluN2C respectively. Also Inhibits voltage- dependent Ca2+ channels. Shows neuroprotective actions and potentiates anticonvulsant effects of CGP 37849.
Solubility & Handling
Soluble in DMSO (25mM)
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.