Product overview

Name E6 Berbamine
Alternative names E6; Berbamine compound E6
Description Potent, selective CaM antagonist
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Biological Data

Biological description Potent and selective calmodulin (CaM) antagonist. Inhibits MLCK activity (Ki = 0.95 µM) and P-glycoprotein (P-gp) activity in vascular endothelial cells. Inhibits α3-containing neuronal nicotinic acetylcholine receptors (α3-nAChRs). Cell-permeable.

Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in DMSO (25mg/ml) or ethanol (25mg/ml)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Chemical name 6,6',7-Trimethoxy-2,2'-dimethylberbaman-12-yl acetate; Calmodulin inhibitor
Molecular Weight 757.83
Chemical structure E6 Berbamine  [73885-53-7] Chemical Structure
Molecular Formula C44H43N3O9
CAS Number 73885-53-7
SMILES COc1cc2CCN(C)C3Cc4ccc(Oc5cc(CC6N(C)CCc7cc(OC)c(OC)c(Oc1cc23)c67)ccc5OC(C)=O)cc4

References for E6 Berbamine

References are publications that support the biological activity of the product
  • Differential inhibition of rat alpha3* and alpha7 nicotinic acetylcholine receptors by tetrandrine and closely related bis-benzylisoquinoline derivatives.

    Virginio C et al (2005) Neurosci Lett 381(3) : 299-304.
  • Effect of E6, a novel calmodulin inhibitor, on activity of P-glycoprotein in purified primary cultured rat brain microvessel endothelial cells.

    Zhu HJ et al (2003) Acta Pharmacol Sin 24(11) : 1143-9.
  • Interaction of berbamine compound E6 and calmodulin-dependent myosin light chain kinase.

    Hu ZY et al (1992) Biochem Pharmacol 44(8) : 1543-7.

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