Product overview

Name E6 Berbamine
Alternative names E6; Berbamine compound E6
Description Potent, selective CaM antagonist
Write Your Own Review
You're reviewing:E6 Berbamine
Rate this item:

Biological Data

Biological description Potent and selective calmodulin (CaM) antagonist. Inhibits MLCK activity (Ki = 0.95 µM) and P-glycoprotein (P-gp) activity in vascular endothelial cells. Inhibits α3-containing neuronal nicotinic acetylcholine receptors (α3-nAChRs). Cell-permeable.

Solubility & Handling

Solubility overview Soluble in DMSO (25mg/ml) or ethanol (25mg/ml)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



More Info


More Info

Chemical Data

Chemical name 6,6',7-Trimethoxy-2,2'-dimethylberbaman-12-yl acetate; Calmodulin inhibitor
Molecular Weight 757.83
Chemical structure E6 Berbamine  [73885-53-7] Chemical Structure
Molecular Formula C44H43N3O9
CAS Number 73885-53-7
SMILES COc1cc2CCN(C)C3Cc4ccc(Oc5cc(CC6N(C)CCc7cc(OC)c(OC)c(Oc1cc23)c67)ccc5OC(C)=O)cc4

References for E6 Berbamine

References are publications that support the biological activity of the product
  • Differential inhibition of rat alpha3* and alpha7 nicotinic acetylcholine receptors by tetrandrine and closely related bis-benzylisoquinoline derivatives.

    Virginio C et al (2005) Neurosci Lett 381(3) : 299-304.
  • Effect of E6, a novel calmodulin inhibitor, on activity of P-glycoprotein in purified primary cultured rat brain microvessel endothelial cells.

    Zhu HJ et al (2003) Acta Pharmacol Sin 24(11) : 1143-9.
  • Interaction of berbamine compound E6 and calmodulin-dependent myosin light chain kinase.

    Hu ZY et al (1992) Biochem Pharmacol 44(8) : 1543-7.

3 Item(s)