Potent and selective calmodulin (CaM) antagonist. Inhibits MLCK activity (Ki = 0.95 µM) and P-glycoprotein (P-gp) activity in vascular endothelial cells. Inhibits α3-containing neuronal nicotinic acetylcholine receptors (α3-nAChRs). Cell-permeable.
Solubility & Handling
Solubility overview
Soluble in DMSO (25mg/ml) or ethanol (25mg/ml)
Storage instructions
-20°C
Storage of solutions
Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions
Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References are publications that support the biological activity of the product
Differential inhibition of rat alpha3* and alpha7 nicotinic acetylcholine receptors by tetrandrine and closely related bis-benzylisoquinoline derivatives.
Virginio C et al (2005) Neurosci Lett 381(3) : 299-304.
![E6 Berbamine [73885-53-7] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb0269.png "E6 Berbamine [73885-53-7]")
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