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Biological Data Biological description Potent and selective calmodulin (CaM) antagonist. Inhibits MLCK activity (Ki = 0.95 µM) and P-glycoprotein (P-gp) activity in vascular endothelial cells. Inhibits α3-containing neuronal nicotinic acetylcholine receptors (α3-nAChRs). Cell-permeable.
Solubility & Handling Storage instructions -20°C
Solubility overview Soluble in DMSO (25mg/ml) or ethanol (25mg/ml)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical name 6,6',7-Trimethoxy-2,2'-dimethylberbaman-12-yl acetate; Calmodulin inhibitor
Chemical structure
Molecular Formula C44 H43 N3 O9
SMILES COc1cc2CCN(C)C3Cc4ccc(Oc5cc(CC6N(C)CCc7cc(OC)c(OC)c(Oc1cc23)c67)ccc5OC(C)=O)cc4
References for E6 Berbamine References are publications that support the biological activity of the product
Differential inhibition of rat alpha3* and alpha7 nicotinic acetylcholine receptors by tetrandrine and closely related bis-benzylisoquinoline derivatives. Virginio C et al (2005) Neurosci Lett 381(3) : 299-304. Effect of E6, a novel calmodulin inhibitor, on activity of P-glycoprotein in purified primary cultured rat brain microvessel endothelial cells. Zhu HJ et al (2003) Acta Pharmacol Sin 24(11) : 1143-9. Interaction of berbamine compound E6 and calmodulin-dependent myosin light chain kinase. Hu ZY et al (1992) Biochem Pharmacol 44(8) : 1543-7.
Potent, selective CaM antagonist
![E6 Berbamine [73885-53-7] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb0269.png "E6 Berbamine [73885-53-7]")
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