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Designer receptors exclusively activated by designer drugs (DREADDs) are genetically engineered GPCRs that are activated by physiologically inert synthetic small molecules (designer drugs) but not their endogenous ligand. Read our DREADDs mini-review or for practical advice on using these ligands in the lab see Stability of Water-Soluble DREADD Ligands in Solution: A Technical Review and Clozapine N-Oxide (freebase) - a technical review on stability, solubility and use in the lab).
CP 94253 dihydrochloride (HB1671)
Description:Potent, selective 5-HT1B receptor agonist
Purity:>98%
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Dihydroergocristine mesylate (HB1611)
Description:5-HT antagonist. Also partial agonist at adrenergic and dopaminergic receptors.
Purity:>98%
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LY 272015 hydrochloride (HB1750)
Description:High affinity, selective 5-HT2B receptor antagonist
Purity:>98%
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