Product overview

Name CP 94253 dihydrochloride
Purity >98%
Description Potent, selective 5-HT1B receptor agonist
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Biological Data

Biological description Potent, selective 5-HT1B receptor agonist (Ki values are 2, 89, 49, 860, and 1600 nM at 5-HT1B, 5-HT1A, 5-HT1D, 5-HT1C and 5-HT2 respectively). Reduces foot intake, anticonvulsant and antidepressant-like effects. Active in vivo. Blood-brain barrier permeable.

Solubility & Handling

Storage instructions

Room temperature (desiccate)

Solubility overview

Soluble in water (15mM) amd DMSO (100mM)

Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Purity >98%
Chemical name 5-Propoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-pyrrolo[3,2-b]pyridine dihydrochloride
Molecular Weight 330.3
Chemical structure CP 94253 hydrochloride  [845861-39-4] Chemical Structure
Molecular Formula C15H19N3O.2HCl
CAS Number 845861-39-4
PubChem identifier 11652258
Appearance Pale yellow solid

References for CP 94253 dihydrochloride

References are publications that support the biological activity of the product
  • Effect of 5-HT1B receptor agonists injected into the prefrontal cortex on maternal aggression in rats.

    Veiga CP et al (2007) Braz J Med Biol Res 40(6) : 825-30.
  • Anticonvulsant effect of the selective 5-HT1B receptor agonist CP 94253 in mice.

    Wesołowska A et al (2006) Eur J Pharmacol 541(1-2) : 57-63.
  • Antidepressant-like effect of the selective 5-HT1B receptor agonist CP 94253: a possible mechanism of action.

    Tatarczyńska E et al (2005) Eur J Pharmacol 516(1) : 46-50.
  • Biochemical and behavioral studies of the 5-HT1B receptor agonist, CP-94,253

    Koet et al (1992) Drug dev res 26(3) : 241-250

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