Potent and selective 5-HT2A receptor antagonist (Ki = 0.36 nM). Shows > 80-fold selectivity for 5-HT2A over other 5-HT receptor subtypes. Displays antipsychotic actions. Active in vivo.
Solubility & Handling
Storage instructions
+4°C
Solubility overview
Soluble in DMSO (100 mM) and in 0.05M HCl (50 mM)
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References are publications that support the biological activity of the product
The 5-hydroxytryptamine2A receptor antagonist R-(+)-alpha-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl-4-piperidinemethanol (M100907) attenuates impulsivity after both drug-induced disruption (dizocilpine) and enhancement (antidepressant drugs) of dif
Ardayfio et al (2008) J Pharmacol Exp Ther 327(3) : 891-7
Preclinical characterization of the potential of the putative atypical antipsychotic MDL 100,907 as a potent 5-HT2A antagonist with a favorable CNS safety profile.
Kehne et al (1996) J Pharmacol Exp Ther 277(2) : 968-81
Characterization of the 5-HT2 receptor antagonist MDL 100907 as a putative atypical antipsychotic: behavioral, electrophysiological and neurochemical studies.
Sorensen et al (1993) J Pharmacol Exp Ther 266(2) : 684-91
![MDL 100907 | [139290-65-6] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb1780.png "MDL 100907 | [139290-65-6]")
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