Product overview
| Name | MDL 100907 |
| Description | Potent and selective 5-HT2A receptor antagonist |
| Alternative names | Volinanserin |
| Purity | >98% |
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Biological Data
| Biological description | Potent and selective 5-HT2A receptor antagonist (Ki = 0.36 nM). Shows > 80-fold selectivity for 5-HT2A over other 5-HT receptor subtypes. Displays antipsychotic actions. Active in vivo. |
Solubility & Handling
| Storage instructions | +4°C |
| Solubility overview | Soluble in DMSO (100 mM) and in 0.05M HCl (50 mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Purity | >98% |
| Chemical name | (R)-(+)-α-(2,3-Dimethoxyphenyl)-1-[2 -(4-fluorophenyl)ethyl]-4-piperinemethanol |
| Molecular Weight | 373.46 |
| Chemical structure | ![MDL 100907 | [139290-65-6] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb1780.png "MDL 100907 | [139290-65-6]") |
| Molecular Formula | C22H28FNO3 |
| CAS Number | 139290-65-6 |
| PubChem identifier | 5311271 |
| SMILES | COC1=CC=CC(=C1OC)[C@@H](C2CCN(CC2)CCC3=CC=C(C=C3)F)O |
| Source | Synthetic |
| InChi | InChI=1S/C22H28FNO3/c1-26-20-5-3-4-19(22(20)27-2)21(25)17-11-14-24(15-12-17)13-10-16-6-8-18(23)9-7-16/h3-9,17,21,25H,10-15H2,1-2H3/t21-/m1/s1 |
| InChiKey | HXTGXYRHXAGCFP-OAQYLSRUSA-N |
| MDL number | MFCD00909060 |
| Appearance | White solid |
References for MDL 100907
References are publications that support the biological activity of the product
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The 5-hydroxytryptamine2A receptor antagonist R-(+)-alpha-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl-4-piperidinemethanol (M100907) attenuates impulsivity after both drug-induced disruption (dizocilpine) and enhancement (antidepressant drugs) of dif
Ardayfio et al (2008) J Pharmacol Exp Ther 327(3) : 891-7 -
Preclinical characterization of the potential of the putative atypical antipsychotic MDL 100,907 as a potent 5-HT2A antagonist with a favorable CNS safety profile.
Kehne et al (1996) J Pharmacol Exp Ther 277(2) : 968-81 -
Characterization of the 5-HT2 receptor antagonist MDL 100907 as a putative atypical antipsychotic: behavioral, electrophysiological and neurochemical studies.
Sorensen et al (1993) J Pharmacol Exp Ther 266(2) : 684-91
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