Group I (mGlu5, mGlu1)

Group I metabotropic glutamate receptors (mGlu₁, mGlu₅) are coupled with phospholipase C (PLC) via G_q proteins; activation causes increased levels of IP₃ and diacylglycerol, with intracellullar Ca²⁺ release and protein kinase C (PKC) activation. Group I receptors are predominantly located post synaptically. Researchers can save 50% on group I metabotropic glutamate receptor agonists, antagonists, positive allosteric modulators (PAMs) and negative allosteric modulators (NAMs) from Hello Bio - they are up to half the price of other suppliers.