Product overview

Name Dihydrokainic acid
Description Competitive, selective EAAT2 inhibitor
Alternative names DHK, Dihydrokainate
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Biological Data

Biological description

Selective EAAT2 (GLT1) inhibitor (Ki = 23 µM). 130-fold selective over EAAT1 and EAAT3 (Ki >3 mM). Twice as potent as kainic acid in inhibiting high affinity L-Glu uptake. Weakly excites neurons.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in water (25mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Chemical Data

Chemical name (2S,3S,4R)-2-Carboxy-4-isopropyl-3-pyrrolidineaceticacid
Molecular Weight 215.25
Chemical structure Dihydrokainic acid  [52497-36-6] Chemical Structure
Molecular Formula C10H17NO4
CAS Number 52497-36-6
PubChem identifier 107883
SMILES O=C(C[C@H]1[C@@H]([C@H](C)C)CN[C@@H]1[C@](O)=O)O
Source Synthetic
InChi InChI=1S/C10H17NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h5-7,9,11H,3-4H2,1-2H3,(H,12,13)(H,14,15)/t6-,7+,9-/m0/s1
InChiKey JQPDCKOQOOQUSC-OOZYFLPDSA-N
MDL number MFCD03412037
Appearance White solid

References for Dihydrokainic acid

References are publications that support the biological activity of the product
  • Effect of dihydrokainate on the capacity of repair of DNA damage and apoptosis induced by doxorubicin.

    Attia SM et al (2013) Mutagenesis 28(3) : 257-61.
  • A microdialysis study in rat brain of dihydrokainate, a glutamate uptake inhibitor.

    Fallgren AB et al (1996) Neurochem Res 21(1) : 19-25.
  • Kainic acid, AMPA, and dihydrokainic acid effect on uptake and efflux of D-[3H] aspartic acid in cerebellar slices.

    Bouazzaoui M et al (1996) Neurochem Res 21(12) : 1527-33.
  • Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex.

    Arriza JL et al (1994) J Neurosci 14(9) : 5559-69.