Dihydrokainic acid
(HB0246)
Product overview
| Name | Dihydrokainic acid |
| Description | Competitive, selective EAAT2 inhibitor |
| Alternative names | DHK, Dihydrokainate |
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Biological Data
| Biological description | Selective EAAT2 (GLT1) inhibitor (Ki = 23 µM). 130-fold selective over EAAT1 and EAAT3 (Ki >3 mM). Twice as potent as kainic acid in inhibiting high affinity L-Glu uptake. Weakly excites neurons. |
Solubility & Handling
| Storage instructions | Room temperature |
| Solubility overview | Soluble in water (25mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | (2S,3S,4R)-2-Carboxy-4-isopropyl-3-pyrrolidineaceticacid |
| Molecular Weight | 215.25 |
| Chemical structure | ![Dihydrokainic acid [52497-36-6] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb0246.png "Dihydrokainic acid [52497-36-6]") |
| Molecular Formula | C10H17NO4 |
| CAS Number | 52497-36-6 |
| PubChem identifier | 107883 |
| SMILES | O=C(C[C@H]1[C@@H]([C@H](C)C)CN[C@@H]1[C@](O)=O)O |
| Source | Synthetic |
| InChi | InChI=1S/C10H17NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h5-7,9,11H,3-4H2,1-2H3,(H,12,13)(H,14,15)/t6-,7+,9-/m0/s1 |
| InChiKey | JQPDCKOQOOQUSC-OOZYFLPDSA-N |
| MDL number | MFCD03412037 |
| Appearance | White solid |
References for Dihydrokainic acid
References are publications that support the biological activity of the product
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Effect of dihydrokainate on the capacity of repair of DNA damage and apoptosis induced by doxorubicin.
Attia SM et al (2013) Mutagenesis 28(3) : 257-61. -
A microdialysis study in rat brain of dihydrokainate, a glutamate uptake inhibitor.
Fallgren AB et al (1996) Neurochem Res 21(1) : 19-25. -
Kainic acid, AMPA, and dihydrokainic acid effect on uptake and efflux of D-[3H] aspartic acid in cerebellar slices.
Bouazzaoui M et al (1996) Neurochem Res 21(12) : 1527-33. -
Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex.
Arriza JL et al (1994) J Neurosci 14(9) : 5559-69.
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