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Biological Data Biological description Selective EAAT2 (GLT1) inhibitor (Ki = 23 µM). 130-fold selective over EAAT1 and EAAT3 (Ki >3 mM). Twice as potent as kainic acid in inhibiting high affinity L-Glu uptake. Weakly excites neurons.
Solubility & Handling Storage instructions Room temperature
Solubility overview Soluble in water (25mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical name (2S ,3S ,4R )-2-Carboxy-4-isopropyl-3-pyrrolidineaceticacid
Chemical structure
Molecular Formula C10 H17 NO4
PubChem identifier 107883
SMILES O=C(C[C@H]1[C@@H]([C@H](C)C)CN[C@@H]1[C@](O)=O)O
InChi InChI=1S/C10H17NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h5-7,9,11H,3-4H2,1-2H3,(H,12,13)(H,14,15)/t6-,7+,9-/m0/s1
InChiKey JQPDCKOQOOQUSC-OOZYFLPDSA-N
References for Dihydrokainic acid References are publications that support the biological activity of the product
Effect of dihydrokainate on the capacity of repair of DNA damage and apoptosis induced by doxorubicin. Attia SM et al (2013) Mutagenesis 28(3) : 257-61. A microdialysis study in rat brain of dihydrokainate, a glutamate uptake inhibitor. Fallgren AB et al (1996) Neurochem Res 21(1) : 19-25. Kainic acid, AMPA, and dihydrokainic acid effect on uptake and efflux of D-[3H] aspartic acid in cerebellar slices. Bouazzaoui M et al (1996) Neurochem Res 21(12) : 1527-33. Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex. Arriza JL et al (1994) J Neurosci 14(9) : 5559-69.
Competitive, selective EAAT2 inhibitor
![Dihydrokainic acid [52497-36-6] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb0246.png "Dihydrokainic acid [52497-36-6]")
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