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Dihydrokainic acid

(HB0246)
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Product overview

Name Dihydrokainic acid
Alternative names DHK, Dihydrokainate
Description Competitive, selective EAAT2 inhibitor
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (4) Reviews References (4) Frequently bought together
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Biological Data

Biological description

Selective EAAT2 (GLT1) inhibitor (Ki = 23 µM). 130-fold selective over EAAT1 and EAAT3 (Ki >3 mM). Twice as potent as kainic acid in inhibiting high affinity L-Glu uptake. Weakly excites neurons.

Solubility & Handling

Solubility overview Soluble in water (25mM)
Storage instructions Room temperature
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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More Info

Dilution

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Chemical Data

Chemical name (2S,3S,4R)-2-Carboxy-4-isopropyl-3-pyrrolidineaceticacid
Molecular Weight 215.25
Chemical structure Dihydrokainic acid [52497-36-6] Chemical Structure
Molecular Formula C10H17NO4
CAS Number 52497-36-6
PubChem identifier 107883
SMILES O=C(C[C@H]1[C@@H]([C@H](C)C)CN[C@@H]1[C@](O)=O)O
Source Synthetic
InChi InChI=1S/C10H17NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h5-7,9,11H,3-4H2,1-2H3,(H,12,13)(H,14,15)/t6-,7+,9-/m0/s1
InChiKey JQPDCKOQOOQUSC-OOZYFLPDSA-N
MDL number MFCD03412037
Appearance White solid

References for Dihydrokainic acid

References are publications that support the biological activity of the product

  • Effect of dihydrokainate on the capacity of repair of DNA damage and apoptosis induced by doxorubicin.

    Attia SM et al (2013) Mutagenesis 28(3) : 257-61.
    Read more (PubMedID: 23360835)

  • A microdialysis study in rat brain of dihydrokainate, a glutamate uptake inhibitor.

    Fallgren AB et al (1996) Neurochem Res 21(1) : 19-25.
    Read more (PubMedID: 8833219)

  • Kainic acid, AMPA, and dihydrokainic acid effect on uptake and efflux of D-[3H] aspartic acid in cerebellar slices.

    Bouazzaoui M et al (1996) Neurochem Res 21(12) : 1527-33.
    Read more (PubMedID: 8953569)

  • Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex.

    Arriza JL et al (1994) J Neurosci 14(9) : 5559-69.
    Read more (PubMedID: 7521911)

4 Item(s)

Related Products
Grouped product items
Order: HB0246
Pack PriceQty
1mg
$69
10mg
$142
50mg
$605
Competitive, selective EAAT2 inhibitor
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

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