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5,7-Dichlorokynurenic acid: Scientist Approved
5,7-Dichlorokynurenic acid: Scientist Approved
Biological Data
| Biological description | Potent, selective and competitive NMDA receptor antagonist (Ki = 79 nM). Binds at the glycine site. Neuroprotective actions in cell culture. |
Solubility & Handling
| Storage instructions | Room temperature |
| Solubility overview | Soluble in 0.1M NaOH (100mM) and in DMSO (100mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use |
Chemical Data
| Chemical name | 5,7-Dichloro-4-hydroxyquinoline-2-carboxylic acid |
| Chemical structure | ![5,7-Dichlorokynurenic acid [131123-76-7] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "5,7-Dichlorokynurenic acid [131123-76-7]") |
| Molecular Formula | C10H5Cl2NO3 |
| SMILES | C1=C(C=C2C(=C1Cl)C(=O)C=C(N2)C(=O)O)Cl |
| InChi | InChI=1S/C10H5Cl2NO3/c11-4-1-5(12)9-6(2-4)13-7(10(15)16)3-8(9)14/h1-3H,(H,13,14)(H,15,16) |
| InChiKey | BGKFPRIGXAVYNX-UHFFFAOYSA-N |
References for 5,7-Dichlorokynurenic acid
References are publications that support the biological activity of the product
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Activity of 5,7-dichlorokynurenic acid, a potent antagonist at the N-methyl-D-aspartate receptor-associated glycine binding site.
Baron BM et al (1990) Mol Pharmacol 38(4) : 554-61. -
5,7-Dichlorokynurenic acid, a potent and selective competitive antagonist of the glycine site on NMDA receptors.
McNamara D et al (1990) Neurosci Lett 120(1) : 17-20.
Publications
These publications cite the use of 5,7-Dichlorokynurenic acid purchased from Hello Bio:
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Structural Basis for Negative Allosteric Modulation of GluN2A-Containing NMDA Receptors.
Yi et al (2016) Neuron 91(6) : 1316-29
Potent, selective, competitive glycine site NMDA receptor antagonist
![5,7-Dichlorokynurenic acid [131123-76-7] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb0078.png "5,7-Dichlorokynurenic acid [131123-76-7]")
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