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5,7-Dichlorokynurenic acid

(HB0078)
Publications (1)
Technical documents: SDS Datasheet
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Product overview

Name 5,7-Dichlorokynurenic acid
Alternative names DCKA; 5,7-DCK
Purity >98%
Description Potent, selective, competitive glycine site NMDA receptor antagonist
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (4) Reviews Publications (1) References (2) Frequently bought together
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5,7-Dichlorokynurenic acid: Scientist Approved
5,7-Dichlorokynurenic acid: Scientist Approved

5,7-Dichlorokynurenic acid: Scientist Approved

5,7-Dichlorokynurenic acid: Scientist Approved

Biological Data

Biological description Potent, selective and competitive NMDA receptor antagonist (Ki = 79 nM). Binds at the glycine site. Neuroprotective actions in cell culture.

Solubility & Handling

Solubility overview Soluble in 0.1M NaOH (100mM) and in DMSO (100mM)
Storage instructions Room temperature
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name 5,7-Dichloro-4-hydroxyquinoline-2-carboxylic acid
Molecular Weight 258.06
Chemical structure 5,7-Dichlorokynurenic acid [131123-76-7] Chemical Structure
Molecular Formula C10H5Cl2NO3
CAS Number 131123-76-7
PubChem identifier 1779
SMILES C1=C(C=C2C(=C1Cl)C(=O)C=C(N2)C(=O)O)Cl
InChi InChI=1S/C10H5Cl2NO3/c11-4-1-5(12)9-6(2-4)13-7(10(15)16)3-8(9)14/h1-3H,(H,13,14)(H,15,16)
InChiKey BGKFPRIGXAVYNX-UHFFFAOYSA-N
MDL number MFCD00083173

References for 5,7-Dichlorokynurenic acid

References are publications that support the biological activity of the product

  • Activity of 5,7-dichlorokynurenic acid, a potent antagonist at the N-methyl-D-aspartate receptor-associated glycine binding site.

    Baron BM et al (1990) Mol Pharmacol 38(4) : 554-61.
    Read more (PubMedID: 2172769)

  • 5,7-Dichlorokynurenic acid, a potent and selective competitive antagonist of the glycine site on NMDA receptors.

    McNamara D et al (1990) Neurosci Lett 120(1) : 17-20.
    Read more (PubMedID: 2149877)

2 Item(s)

Publications
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These publications cite the use of 5,7-Dichlorokynurenic acid purchased from Hello Bio:

  • Structural Basis for Negative Allosteric Modulation of GluN2A-Containing NMDA Receptors.

    Yi et al (2016) Neuron 91(6) : 1316-29
    PubMedID: 27618671

1 Item

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Grouped product items
Order: HB0078
Pack PriceQty
5mg
$58
10mg
$96
25mg
$212
50mg
$389
Potent, selective, competitive glycine site NMDA receptor antagonist
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