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Diazoxide

(HB0244)
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Product overview

Name Diazoxide
Purity >98%
Description Selective KIR6 activator
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (4) Frequently bought together
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Biological Data

Biological description Selective KIR6 (ATP-sensitive K+) channel activator. Increases EPSCs to around 150% of control values. Shows cardioprotective actions during ischaemic injury by activating PKCε. Also shows neuroprotective and antihypertensive actions.

Solubility & Handling

Solubility overview Soluble in DMSO (100mM)
Storage instructions Room temperature
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name 7-Chloro-3-methyl-2H-1,2,4-benzothiadiazine1,1-dioxide
Molecular Weight 230.67
Chemical structure Diazoxide [364-98-7] Chemical Structure
Molecular Formula C8H7ClN2O2S
CAS Number 364-98-7
PubChem identifier 3019
SMILES CC1=NC2=C(C=C(Cl)C=C2)S(=O)(=O)N1
InChiKey GDLBFKVLRPITMI-UHFFFAOYSA-N

References for Diazoxide

References are publications that support the biological activity of the product

  • The neuroprotective effect of diazoxide is mediated by mitochondrial ATP-dependent potassium channels in a rat model of acute subdural hematoma.

    Nakagawa I et al (2013) J Clin Neurosci 20(1) : 144-7.
    Read more (PubMedID: 23036174)

  • Diazoxide acts more as a PKC-epsilon activator, and indirectly activates the mitochondrial K(ATP) channel conferring cardioprotection against hypoxic injury.

    Kim MY et al (2006) Br J Pharmacol 149(8) : 1059-70.
    Read more (PubMedID: 17043673)

  • Towards selective Kir6.2/SUR1 potassium channel openers, medicinal chemistry and therapeutic perspectives.

    Hansen JB (2006) Curr Med Chem 13(4) : 361-76.
    Read more (PubMedID: 16475928)

  • Diazoxide blocks glutamate desensitization and prolongs excitatory postsynaptic currents in rat hippocampal neurons.

    Yamada KA et al (1992) J Physiol 458 : 409-23.
    Read more (PubMedID: 1302270)

4 Item(s)

Related Products
Grouped product items
Order: HB0244
Pack PriceQty
500mg
$131
1g
$193
Selective KIR6 activator
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

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