Selective KIR6 (ATP-sensitive K+) channel activator. Increases EPSCs to around 150% of control values. Shows cardioprotective actions during ischaemic injury by activating PKCε. Also shows neuroprotective and antihypertensive actions.
Solubility & Handling
Solubility overview
Soluble in DMSO (100mM)
Storage instructions
Room temperature
Storage of solutions
Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions
Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Diazoxide acts more as a PKC-epsilon activator, and indirectly activates the mitochondrial K(ATP) channel conferring cardioprotection against hypoxic injury.
Kim MY et al (2006) Br J Pharmacol 149(8) : 1059-70.