Group I (mGlu5, mGlu1)
Group I metabotropic glutamate receptors (mGlu1, mGlu5) are coupled with phospholipase C (PLC) via Gq proteins; activation causes increased levels of IP3 and diacylglycerol, with intracellullar Ca2+ release and protein kinase C (PKC) activation. Group I receptors are predominantly located post synaptically. Researchers can save 50% on group I metabotropic glutamate receptor agonists, antagonists, positive allosteric modulators (PAMs) and negative allosteric modulators (NAMs) from Hello Bio - they are up to half the price of other suppliers.
Necrostatin-5 (HB3994)
Description:Necroptosis inhibitor. Indirect RIP1 kinase inhibitor.
Purity:>98%
Necrostatin-7 (HB3995)
Description:Necroptosis inhibitor. Shows no action at RIP1 kinase.
Purity:>98%
Neuropathiazol (HB3105)
Description:Selective neuronal differentiation inducer in hippocampal neural progenitors
Purity:>98%
22-NHC (inactive isomer) (HB3719)
Description:Inactive control compound for hedgehog signaling inhibitor 22-NHC
Purity:>98%
Niclosamide (HB1435)
Description:STAT3 signaling pathway inhibitor. Antineoplastic against AML stem cells.
Purity:>98%