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G protein coupled receptors

Metabotropic glutamate

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Adenosine

A₁

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Non-selective

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α₁

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Non-selective

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Non-selective

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Non-selective

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B₂

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CB₁

Chemokine

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Non-selective

DREADD

Endothelin

Endothelin B

Non-selective

Estrogen (GPER / GPR30)

GABA-B

Miscellaneous

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H₁

H₂

Non-selective

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LTD4

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CCK2

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Non-selective

Formyl peptide

Glucagon and related

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Ghrelin

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Motilin

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Purinergic: P2Y

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P2Y₁₂

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Non-selective

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Non-selective

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Smo

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RSTKs

TGF-β

BMP/Activin

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Aryl hydrocarbon receptor

Estrogen and related

Estrogen-α

Estrogen-β

Non-selective

Farnesoid X

Glucocorticoid

Mineralocorticoid

Other

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PPARγ

PPARδ

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Retinoic Acid (RAR)

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Dopamine (DAT)

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VGAT

Glucose

Glucose transporter 4

Glutamate uptake & transport

Glycine

Monoamine

VMAT2

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Na⁺/Ca²⁺ exchangers

Na⁺/H⁺ exchangers

5-HT uptake & transport

SGLT

SGLT-2

Norepinephrine (NET)

Other

σ

σ1

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Imidazoline I₂

Ion channels

Ligand-gated ion channel

Ionotropic glutamate receptors

AMPA

NMDA

GluN1

GluN2

GluN2A

GluN2B

GluN2C

GluN2D

Kainate

Miscellaneous

Non-selective ionotropic glutamate

Purinergic: P2X

P2X₄

P2X₇

Non-selective

Acid-sensing (proton-gated) (ASICs)

GABA-A

IP₃

Glycine

Nicotinic AcH

α3β4

α4β2

α7

Non-selective

PSEMS

5-HT₃

Voltage-gated ion channel

Sodium Channels

Potassium Channels

Voltage-gated (K_v)

Two-P

BK channels

Calcium activated (K_Ca)

Inwardly rectifying (K_ir)

Ryanodine receptor

Non-selective

Calcium Channels

Ca_v1.x (L-type)

Ca_v2.x

Ca_v3.x (T-type)

Cyclic nucleotide-regulated channels

TRP

TRPA

TRPC

TRPC6

TRPM

TRPV

Other

Ionophores

Piezo

Enzymes

ATPase / GTPase

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H⁺-ATPase

Myosin ATPase

Na⁺/K⁺ ATPase

Cyclase

Adenylyl cyclase

Guanylyl cyclase

Deacetylase

Histone deacetylase (HDAC)

Non-selective

Sirtuin

SIRT2

Sir2P

Deaminase

XMP aminase

Demethylase

Histone demethylase

Dehydrogenase

Aldehyde Dehydrogenase

Monophosphatase dehydrogenase

Esterase

Acetylcholinesterase

Lipase

Phospholipase

Glycosylase

Glucosidase

α

Hydrolase

FAAH

GCH1 (GTP cyclohydrolase I)

Helicase

Hydroxylase

Tryptophan hydroxylase

Tyrosine Hydroxylase

Isomerase

DNA Topoisomerase

DNA Gyrase

Type 1

Type 2

Kinase

Abl

Akt / PKB

AMPK

Aurora kinase

Aurora Kinase A

Aurora Kinase B

Non-selective

BTK

CAM Kinase II

Casein kinase

CDK

CDK1

CDK2

Non-selective

c-Src

DYRK

ERK

ERK2 / MAPK1

GRK

Non-selective

GSK-3

Hexokinase

JAK

MAPK

p38 MAPK

MEK

MEK1

JNK

MAPKAP

MAPKAP2

mTOR

Myosin light chain kinase (MLCK)

Non-selective

PKA

PKC

PKG

PI-3K

Protein-serine/threonine kinase

Protein-tyrosine kinase

Non-selective

RIP kinase

RIP1

ROCK

RSK

Sphingosine kinase

Syk

Raf

B-Raf

c-RAF

Ligase

Ubiquitin/Ubl E2 conjugating

Ub-conjugating enzyme (E2) complex

Oxidase

Monoamine Oxidase

Non-selective

Tyrosinase

Oxygenase

COX

COX-2

5-lipoxygenase

Phosphodiesterase

PDE1

PDE4

Non-selective

Sphingomyelinase

N-Smase

Phosphatase

Alkaline phosphatase

Phosphoprotein phosphatase

Protein Phosphatase 1 (PP1)

PP2A

Calcineurin / PP2B

PP4

Protein serine/threonine phosphatase (PSP)

CAPP (Ceramide-activated protein phosphatase)

Protein-tyrosine phosphatase

PTP1B

Polymerase

DNA/RNA

Tankyrase (TNKS)

Telomerase

Protease / Peptidase

ACE2

Aminopeptidase

Angiotensin-Converting Enzyme (ACE)

Aspartic protease

Calpains

Caspase

Broad

Cathepsin

Cathepsin B

Deubiquitinating Enzymes

Ubiquitin C-terminal hydrolase

Dipeptidyl-peptidase 4

Elastase

Matrix metalloprotease

MMP-1

Methionine aminopeptidase-2

Other

Protease inhibitors and inhibitor cocktails

Prolyl endopeptidase (PREP)

Proteasome

Serine/cysteine protease

Secretase

γ

Reductase

Aldose reductase

NADH ubiquinone oxidoreductase

Synthase

HMG-CoA synthase

NOS

Transferase

ACAT

DGAT

DNA methyltransferase (DNMT)

Histone acetyltransferase (HAT)

Histone methyltransferase (HMTs)

Phosphorylase

Protein prenyltransferases

PORCN

Tankyrase (TNKS)

Proteins - Other

Actin

Choline ester transfer protein (CETP)

GAPDH

GFAP

GFP

Histones

Bromodomain

Histone H3

HSP60

MAP2

mCherry

NeuN

Neurofilament L

Neurofilament M

N-WASP

Plasminogen PAI-1

STAT

Tubulin

βIII-tubulin

β-tubulin

Myelin basic protein

c-Fos

Vimentin

GST

Calcium binding proteins

Calmodulin

Parvalbumin

Calretinin

Calbindin

Ki-67

IBA1

Cell signaling

PI3K/Akt/mTOR

Akt

PI3K

mTOR

TGF-Beta/SMAD/ROCK

Bcr-Abl

ROCK

TGF-Beta/ SMAD

MAPK

p38 MAPK

MEK

ERK

ERK2 / MAPK1

JNK

Raf

Estrogen & other Nuclear Receptors

Aryl Hydrocarbon Receptors

Estrogen Receptor signaling

Estrogen-α

Estrogen-β

Non-selective

Estrogen GPER receptors

PPAR

Wnt/Beta-Catenin signaling

β-catenin

Anticancer

Cytotoxic

Anti-oxidant

Mitochondrial complex II

Cyclic nucleotide and related

Adenylyl cyclase (AC)

cAMP

Guanyl cyclase (GC)

Inositol trisphosphate (IP3)

PKA

PKC

Ca²⁺ signaling

Ca²⁺-ATPase (SERCA)

Ca²⁺ binding protein

Ca²⁺-sensitive protease

General compounds

Na⁺/Ca²⁺ exchanger

Mitochondrial permeability transition pore (MPTP)

Gap channels (gap junctions)

G protein

Small monomeric GTPase

G Protein (Heterotrimeric)

Heatshock proteins

HSP90

Hedgehog signaling

Lipid signaling

Nitric oxide

Notch

Transcription factors

HIF

NFAT

NGF

Stats

Cell process

COVID-19 Research

Compound repurposing

Virus attachment / entry

TMPRSS2

ACE2

Endocytosis

Virus replication, transcription & maturation

RNA Polymerases (RdRP/ RNAP)

Endocytosis / Endosome

Viral proteases

Cytokine Storm / Immune response signaling

Angiotensin related

Cytokines, chemokines & NF-κB/I-κB

Chemokine Receptors

Cytokine Stimulation/ Production

NF-κB / IκB

Inflammasomes

JAK/STAT

MAPK Signaling

p38 MAPK

MEK

ERK

ERK2 / MAPK1

JNK

Raf

PI3K/Akt/mTOR

Akt

PI3K

mTOR

Protease-Activated Receptors

TLR (Toll-like receptors) signaling

TLR2

TLR7

Organoids

Cell culture reagents & buffers

Selection Antibiotics

Protease inhibitor cocktails and inhibitors

Cell stains, viability & proliferation

CRISPR/ Gene editing

Apoptosis & cell cycle

Caspase

Inducers

p53

PARP

PARP-1

Non-selective

RIP kinase

Stains

Cell Metabolism

Autophagy

Amyloid-β

Bioactive metabolites

DNA / RNA & protein synthesis

Genome editing / engineering

Oxidative Phosphorylation

Ubiquitin-proteasome system (UPS)

Cytoskeleton and Extracellular Matrix

Actin

Matrix Metalloproteases (MMP)

Microtubule

PI3K/Akt/mTOR

PI3K

ROCK (Rho-kinase)

Immunology & Inflammation

Antivirals / Antibiotics / immunomodulators

Antibiotics

Antimicrobials

Antivirals

COVID-19/SARS-CoV-2 related

Immunosupressants / immunomodulators

Mycotoxin

T-cell Related

Cytokines, chemokines & NF-κB/I-κB

Chemokine Receptors

Cytokine Stimulation/ Production

JNK

NF-κB / IκB

Inflammasome

JAK/STAT

TLR (Toll-like receptors)

TLR2

TLR7

Non-selective

Oxidative Stress

ROS

NOS

Stem cells

Dedifferentiation

Differentiation

iPSCs & ESCs

Mesenchymal Stem cells (MSCs)

Neural Stem Cells (NSCs)

Neurotrophins

Organoids

Proliferation, self-renewal, maintenance

Reprogramming

Stem cell signaling

Proliferation

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