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Designer receptors exclusively activated by designer drugs (DREADDs) are genetically engineered GPCRs that are activated by physiologically inert synthetic small molecules (designer drugs) but not their endogenous ligand. Read our DREADDs mini-review or for practical advice on using these ligands in the lab see Stability of Water-Soluble DREADD Ligands in Solution: A Technical Review and Clozapine N-Oxide (freebase) - a technical review on stability, solubility and use in the lab).
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LIH383 (HB9242)
Description:Potent and selective ACKR3 (CXCR7) agonist. Potentiates opioid peptide activity.
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LUF7487 (HB9585)
Description:Novel, covalent Affinity-Based Probe (AfBP). Clickable antagonist for the A2AR.
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Novel, intracellular covalent chemokine CCR2 negative allosteric modulator (NAM). Binds irreversibly.
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