Product overview

Name LUF7602
Biological description

Novel, potent, selective A3AR covalent antagonist (apparent pKi values at A3ARs are 6.9 and 8.0 (after 4h), where a Ki shift indicates a covalent mode of action). Binds irreversibly.

Sold under license from the Oncode Institute and Universiteit Leiden

Purity >95%
Description

Novel, potent, selective A3AR covalent antagonist

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Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in DMSO
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

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Dilution

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Chemical Data

Purity >95%
Chemical name 4-[3-(8-Methoxy-2,4-dioxo-3-propylpurino[7,8-a]pyridin-1-yl)propylcarbamoyl]benzenesulfonyl fluoride
Molecular Weight 517.5
Chemical structure  Chemical Structure
Molecular Formula C23H24FN5O6S
PubChem identifier 155513958
SMILES CCCN1C(=O)C2=C(N=C3N2C=CC(=C3)OC)N(C1=O)CCCNC(=O)C4=CC=C(C=C4)S(=O)(=O)F
InChiKey QNCALQNHCSHYFR-UHFFFAOYSA-N
Licensing details

Sold under license from the Oncode Cancer Institute and Universiteit Leiden

References for LUF7602

References are publications that support the biological activity of the product
  • Development of Covalent Ligands for G Protein-Coupled Receptors: A Case for the Human Adenosine A(3) Receptor.

    Yang X et al (2019) Journal of medicinal chemistry 62 : 3539-3552

1 Item