Product overview

Name LUF7602
Biological description

Novel, potent, selective A3AR covalent antagonist (apparent pKi values at A3ARs are 6.9 and 8.0 (after 4h), where a Ki shift indicates a covalent mode of action). Binds irreversibly.

Sold under license from the Oncode Institute and Universiteit Leiden

Purity >95%
Description

Novel, potent, selective A3AR covalent antagonist

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Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in DMSO
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

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Dilution

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Chemical Data

Purity >95%
Chemical name 4-[3-(8-Methoxy-2,4-dioxo-3-propylpurino[7,8-a]pyridin-1-yl)propylcarbamoyl]benzenesulfonyl fluoride
Molecular Weight 517.5
Chemical structure  Chemical Structure
Molecular Formula C23H24FN5O6S
PubChem identifier 155513958
SMILES CCCN1C(=O)C2=C(N=C3N2C=CC(=C3)OC)N(C1=O)CCCNC(=O)C4=CC=C(C=C4)S(=O)(=O)F
InChiKey QNCALQNHCSHYFR-UHFFFAOYSA-N
Licensing details

Sold under license from the Oncode Cancer Institute and Universiteit Leiden

References for LUF7602

References are publications that support the biological activity of the product
  • Development of Covalent Ligands for G Protein-Coupled Receptors: A Case for the Human Adenosine A(3) Receptor.

    Yang X et al (2019) Journal of medicinal chemistry 62 : 3539-3552

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