LUF7445

(HB8439)

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Product overview

Name LUF7445
Biological description

Novel, potent covalent A2A antagonist (apparent pKi values at A2ARs are 8.27 (after 0.5h) and 8.99 (after 3h), where a Ki shift indicates a covalent mode of action). Binds irreversibly.

Sold under license from the Oncode Institute and Universiteit Leiden

Purity >95%
Description Novel, potent covalent A2A antagonist. Binds irreversibly.
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Solubility & Handling

Storage instructions -20°C
Storage buffer Soluble in DMSO
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

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Dilution

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Chemical Data

Purity >95%
Chemical name 4-[3-[[7-Amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl]amino]propylcarbamoyl]benzenesulfonyl fluoride
Molecular Weight 460.4
Chemical structure  Chemical Structure
Molecular Formula C18H17FN8O4S
PubChem identifier 145958874
SMILES C1=COC(=C1)C2=NN3C(=NC(=NC3=N2)NCCCNC(=O)C4=CC=C(C=C4)S(=O)(=O)F)N
InChiKey NSSXICGPNXURNZ-UHFFFAOYSA-N
Licensing details

Sold under license from the Oncode Cancer Institute and Universiteit Leiden

References for LUF7445

References are publications that support the biological activity of the product

1 Item