Product overview

Name LUF7445
Biological description

Novel, potent covalent A2A antagonist (apparent pKi values at A2ARs are 8.27 (after 0.5h) and 8.99 (after 3h), where a Ki shift indicates a covalent mode of action). Binds irreversibly.

Sold under license from the Oncode Institute and Universiteit Leiden

Purity >95%
Description Novel, potent covalent A2A antagonist. Binds irreversibly.
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Solubility & Handling

Storage instructions -20°C
Storage buffer Soluble in DMSO
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

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Dilution

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Chemical Data

Purity >95%
Chemical name 4-[3-[[7-Amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl]amino]propylcarbamoyl]benzenesulfonyl fluoride
Molecular Weight 460.4
Chemical structure  Chemical Structure
Molecular Formula C18H17FN8O4S
PubChem identifier 145958874
SMILES C1=COC(=C1)C2=NN3C(=NC(=NC3=N2)NCCCNC(=O)C4=CC=C(C=C4)S(=O)(=O)F)N
InChiKey NSSXICGPNXURNZ-UHFFFAOYSA-N
Licensing details

Sold under license from the Oncode Cancer Institute and Universiteit Leiden

References for LUF7445

References are publications that support the biological activity of the product

1 Item