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LUF7982

(HB9905)
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Technical documents: Datasheet

Product overview

Name LUF7982
Biological description

Novel, selective A2B covalent ligand (apparent pKi values at A2BARs are 8.10 and 9.17 (after 4h), where a Ki shift indicates a covalent mode of action). Displays ~100 -fold selectivity for A2B compared to A1, A2A and A3 receptors. LUF7982 covalently targets lysine residue(s) on the receptor and binds persistently in radioligand displacement and wash-out assays. LUF7982 allows for novel ways to interrogate the A2BAR.

Sold under license from the Oncode Institute and Universiteit Leiden

Purity >95%
Description

Novel Selective A2B covalent ligand. Binds irreversibly.

Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (1)
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Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in DMSO
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

Molarity

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More Info

Dilution

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More Info

Chemical Data

Purity >95%
Chemical name 4-(2,6-dioxo-1-propyl-2,3,6,7-tetrahydro-1H-purin-8-yl)benzenesulfonyl fluoride
Molecular Weight 352.3
Chemical structure Chemical Structure
Molecular Formula C14H13FN4O4S
SMILES CCCN1C(=O)NC2=C(NC(=N2)C2=CC=C(C=C2)S(F)(=O)=O)C1=O
InChiKey LDROORXQLOXQKW-UHFFFAOYSA-N
Licensing details

Sold under license from the Oncode Cancer Institute and Universiteit Leiden

References for LUF7982

References are publications that support the biological activity of the product

  • Development of subtype-selective covalent ligands for the adenosine A(2B) receptor by tuning the reactive group.

    Beerkens BLH et al (2022) RSC medicinal chemistry 13 : 850-856
    Read more (PubMedID: 35923720)

1 Item

Related Products
Grouped product items
Order: HB9905
Pack PriceQty
50μg
$275

Novel Selective A2B covalent ligand. Binds irreversibly.

Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

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