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LUF7487

(HB9585)
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Product overview

Name LUF7487
Biological description

Novel, covalent Affinity-Based Probe (AfBP) which is suitable for click-conjugation (e.g. with the Cyanine-3 fluorophore) for visualization applications (e.g. SDS-PAGE). Irreversibly binds to the A2AR (apparent pKi values at A2aAR are 8.41 (after 0.5h) and 8.82 (after 3h), where a Ki indicates a covalent mode of action).

Sold under license from the Oncode Institute and Universiteit Leiden

Purity >95%
Description

Novel, covalent Affinity-Based Probe (AfBP). Clickable antagonist for the A2AR.

Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (1)
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Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in DMSO
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

Molarity

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Dilution

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Chemical Data

Purity >95%
Chemical name 4-[5-[[7-Amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl]amino]pentyl-prop-2-ynylcarbamoyl]benzenesulfonyl fluoride
Molecular Weight 526.5
Chemical structure Chemical Structure
Molecular Formula C23H23FN8O4S
PubChem identifier 145953622
SMILES C#CCN(CCCCCNC1=NC2=NC(=NN2C(=N1)N)C3=CC=CO3)C(=O)C4=CC=C(C=C4)S(=O)(=O)F
InChiKey KGDQUCQGDCWHAI-UHFFFAOYSA-N
Licensing details

Sold under license from the Oncode Cancer Institute and Universiteit Leiden

References for LUF7487

References are publications that support the biological activity of the product

  • An Affinity-Based Probe for the Human Adenosine A(2A) Receptor.

    Yang X et al (2018) Journal of medicinal chemistry 61 : 7892-7901
    Read more (PubMedID: 30080404)

1 Item

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Grouped product items
Order: HB9585
Pack PriceQty
50μg
$275

Novel, covalent Affinity-Based Probe (AfBP). Clickable antagonist for the A2AR.

Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

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